A valuable study of the science behind the medicine, Muscle: Fundamental Biology and Mechanisms of Disease brings together key leaders in muscle biology. These experts provide state-of-the-art insights into the three forms of muscle--cardiac, skeletal, and smooth--from molecular anatomy, basic physiology, disease mechanisms, and targets of therapy. Commonalities and contrasts among these three tissue types are highlighted. This book focuses primarily on the biology of the myocyte.

Table of Contents

• List of Contributors
• Acknowledgments
• Volume 1
• PART I Introduction
• 1. An Introduction to Muscle - Joseph A. Hill and Eric N. Olson
• 2. A History of Muscle - Arnold M. Katz
• PART II Cardiac Muscle
• Section A: Basic Physiology
• 3. Cardiac Myocyte Specification and Differentiation - Benoit C Bruneau and Brian L Black
• 4. Transcriptional Control of Cardiogenesis - Katherine E. Yutzey
• 5. Cardiomyocyte Ultrastructure - A. Martin Cerdes
• 6. Overview of Cardiac Muscle Physiology - John W. Calvert and David J. Lefer
• 7. Ionic Fluxes and Genesis of the Cardiac Action Potential - Yanggan Wang, Deeptankar DeMazumder, and Joseph A. Hill
• 8. C-Protein-Coupled Receptors in the Heart - Melissa L. Martin, Stephen L. Belmonte, Rashmi Ram, Fadia A. Kamal, and Burns C. Blaxall
• 9. Receptor Tyrosine Kinases in Cardiac Muscle - Tiffany L. Shih and Aarif Y. Khakoo
• 10. Communication in the Heart: Cardiokines as Mediators of a Molecular Social Network - Shirin Doroudgar and Christopher C. Clembotski
• 11. Calcium Fluxes and Homeostasis - Donald M. Bers and Steven R. Houser
• 12. Excitation-Contraction Coupling in the Heart - Daniel C. Andersson, Matthew J. Betzenhauser, and Andrew R. Marks
• 13. Role of Sarcomeres in Cellular Tension, Shortening, and Signaling in Cardiac Muscle - R. John Solaro and Leslie A. Leinwand
• 14. Cardiovascular Mechanotransduction - Stephan Dobner, OvidC. Amadi, and Richard T. Lee
• 15. Cardiomyocyte Metabolism: All Is in Flux - Heinrich Taegtmeyer
• 16. Transcriptional Control of Striated Muscle Mitochondrial Biogenesis and Function - Daniel P. Kelly and Richard C. Scarpulla
• 17. Mitochondrial Morphology and Function - Fabio Di Lisa and Luca Scorrano
• 18. Genetics and Genomics in Cardiovascular Gene Discovery - Aravinda Chakravarti and Ashish Kapoor
• 19. Cardiovascular Proteomics: Assessment of Protein Post-Translational Modifications - Miroslava Stastna, Pingbo Zhang, Anne Murphy, and Jennifer E. Van Eyk
• Section B: Adaptations and Response
• 20. Adaption and Responses: Myocardial Innervations and Neural Control - Neil Herring and David J. Paterson
• 21. Regulation of Cardiac Systolic Function and Contractility - Eiki Takimoto and David A. Kass
• 22. Intracellular Signaling Pathways in Cardiac Remodeling - Yibin Wang and Mark Anderson
• 23. Oxidative Stress and Cardiac Muscle - Yasuhiro Maejima, Daniela Zablocki, and Junichi Sadoshima
• 24. Physiologic and Molecular Responses of the Heart to Chronic Exercise - Benjamin Levine and Peter Buttrick
• 25. Epigenetics in Cardiovascular Biology - Roberto Papait, Paola Cattaneo, Michael V.G. Latronico, and Gianluigi Condorelli
• 26. Cardiac MicroRNAs - Eva van Rooij
• 27. Protein Quality Control in Cardiomyocytes - Xuejun Wang and Cam Patterson
• 28. Cardioprotection - David J. Lefer and Roberto Bolli
• 29. Cardiac Fibrosis: Cellular and Molecular Determinants - Hasse Br0nnum and Raghu Kalluri
• 30. Autophagy in Cardiac Physiology and Disease - Joseph A. Hill, Sergio Lavandero, and Beverly A. Rothermel
• 31. Programmed Cardiomyocyte Death in Heart Disease - Gerald W. Dorn II and Richard N. Kitsis
• 32. Wnt and Notch: Potent Regulators of Cardiomyocyte Specification, Proliferation, and Differentiation - Ethan David Cohen and Edward E. Morrisey
• Section C: Myocardial Disease
• 33. Congenital Cardiomyopathies - Jeffrey A. Towbin, Stephanie Ware, and John Lynn Jefferies
• 34. Genetics of Congenital Heart Disease - Bruce D. Celb and Stephanie E. Chin
• 35. Mechanisms of Stress-Induced Cardiac Hypertrophy - Norbert Frey Eric N. Olson, and Joseph A. Hill
• 36. Ischemic Heart Disease - Charles Steenbergen and Nikolaos G. Frangogiannis
• 37. The Pathophysiology of Heart Failure - Anthony J. Muslin
• 38. The Right Ventricle: Reemergence of the Forgotten Ventricle - Stephen L. Archer, John J. Ryan, Stuart Rich, Sandeep Nathan, Kevin Tsai, Amit R. Patel, Yong-Hu Fang, and Lin Piao
• 39. Mammalian Myocardial Regeneration - Bin Zhou, Zhiqiang Lin, and William T. Pu
• 40. The Structural Basis of Arrhythmia - Eugene Kim and Glenn I. Fishman
• 41. Molecular and Cellular Mechanisms of Cardiac Arrhythmias - Deeptankar DeMazumder and Gordon F. Tomaselli
• 42. Genetic Mechanisms of Arrhythmia - Silvia G. Priori, Carlo Napolitano, and Calum A. MacRae
• 43. Infiltrative and Protein Misfolding Myocardial Diseases - Hamilton S. Gillespie and Ivor J. Benjamin
• 44. Cardiac Aging: From Humans to Molecules - James B. Strait and Edward G. Lakatta
• 45. Adrenergic Receptor Polymorphisms in Heart Failure - Stephen B. Liggett
• 46. Cardiac Gene Therapy - Roger J. Hajjar
• 47. Protein Kinases in the Heart: Lessons Learned from Targeted Cancer Therapeutics - Aarif Y. Khakoo and Thomas Force
• 48. Cell Therapy for Cardiac Disease - R. Kannan Mutharasan and Douglas W. Losordo
• 49. Chemical Genetics of Cardiac Regeneration - Jay W. Schneider and Mark Mercola
• 50. Device Therapy for Systolic Ventricular Failure - J. Eduardo Rame and David Spragg
• 51. Novel Therapeutic Targets and Strategies against Myocardial Diseases - Atsuhiko T. Naito, Ichiro Shiojima and Issei Komuro
• Volume 2
• PART III Skeletal Muscle
• Section A: Basic Physiology
• 52. Skeletal Muscle Development - Margaret Buckingham and Alicia Mayeuf
• 53. Skeletal Muscle: Architecture of Membrane Systems - Clara Franzini-Armstrong and Andrew G. Engel
• 54. The Vertebrate Neuromuscular Junction - Young il Lee and Wesley J. Thompson
• 55. Neuromechanical Interactions that Control Muscle Function and Adaptation - Jung A. Kim, Roland R. Roy, and V. Reggie Edgerton
• 56. Control of Resting Ca2+ Concentration in Skeletal Muscle - Jose R. Lopez and Paul D. Allen
• 57. Skeletal Muscle Excitation-Contraction Coupling - Martin F. Schneider and Erick O. Hernandez-Ochoa
• 58. The Contractile Machinery of Skeletal Muscle - Clara Franzini-Armstrong and H. Lee Sweeney
• 59. Skeletal Muscle Metabolism - Morris J. Bimbaum
• 60. Skeletal Muscle Fiber Types - Stefano Schiaffino and Carlo Reggiani
• Section B: Adaptations and Response
• 61. Regulation of Skeletal Muscle Development and Function by microRNAs - Ning Liu and Rhonda Bassel-Duby
• 62. Musculoskeletal Tissue Injury and Repair: Role of Stem Cells, Their Differentiation, and Paracrine Effects - Burhan Charaibeh, Bridget Deasy Mitra Lavasani, James H. Cummins, Yong Li, and Johnny Huard
• 63. Immunological Responses to Muscle Injury - James G. Tidball and Chiara Rinaldi
• 64. Skeletal Muscle Adaptation to Exercise - John J. McCarthy and Karyn A. Esser
• 65. Skeletal Muscle Regeneration - Denis C. Guttridge
• 66. Skeletal Muscle Dystrophin-Glycoprotein Complex and Muscular Dystrophy - Yvonne M. Kobayashi and Kevin P. Campbell
• Section C: Skeletal Muscle Disease
• 67. Statin-Induced Muscle Toxicity: Clinical and Genetic Determinants of Risk - QiPing Feng and Russell A. Wilke
• 68. Myotonic Dystrophy - Charles Thornton
• 69. Facioscapulohumeral Muscular Dystrophy: Unraveling the Mysteries of a Complex Epigenetic Disease - Charis L. Himeda and Charles P. Emerson, Jr
• 70. ECM-Related Myopathies and Muscular Dystrophies - Carsten G. Bönnemann and Nicol C. Voermans
• 71. Molecular Pathogenesis of Skeletal Muscle Abnormalities in Marfan Syndrome - Ronald D. Cohn and Harry C Dietz III
• 72. Diseases of the Nucleoskeleton - Anne T Bertrand, Rabah Ben Yaou and Gisèle Bonne
• 73. Channelopathies of Skeletal Muscle Excitability - Stephen C. Cannon
• 74. Thick and Thin Filament Proteins: Acquired and Hereditary Sarcomeric Protein Diseases - Julien Ochala and Lars Larsson
• 75. Metabolic and Mitochondrial Myopathies - Ronald G. Haller and Salvatore DiMauro
• Section D: Therapeutics
• 76. Gene Therapy of Skeletal Muscle Disorders Using Viral Vectors - Andrea L.H. Arnett, Julian N. Ramos, and Jeffrey S. Chamberlain
• 77. Cell-Based Therapies in Skeletal Muscle Disease - Denis Vallese, Erica Yada, Gillian Butler-Browne, and Vincent Mouly
• 78. Immunological Components of Genetically Inherited Muscular Dystrophies: Duchenne Muscular Dystrophy and Limb-Girdle Muscular Dystrophy Type 2B - Melissa J. Spencer, Irina Kramerova, M. Carrie Miceli, and Kanneboyina Nagaraju
• 79. Myostatin: Regulation, Function, and Therapeutic Applications - Se-Jin Lee
• 80. Insulin-Like Growth Factor I Regulation and Its Actions in Skeletal Muscle Growth and Repair - Elisabeth R. Barton
• 81. Novel Targets and Approaches to Treating Skeletal Muscle Disease - Elizabeth McNally
• PART IV Smooth Muscle
• Section A: Basic Physiology
• 82. Development of the Smooth Muscle Cell Lineage - Nina Bowens and Michael S. Parmacek
• 83. Smooth Muscle Myocyte Ultrastructure and Contractility - Avril V. Somlyo and Marion J. Siegman
• 84. Potassium, Sodium, and Chloride Channels in Smooth Muscle Cells - Keshan M. Thakali, Asif R. Pathan, Sujay V. Kharade, and Nancy J. Rusch
• 85. C-Protein-Coupled Receptors in Smooth Muscle - Angela Wirth and Stefan Offermanns
• 86. Calcium Homeostasis and Signaling in Smooth Muscle - Theodor Burdyga and Richard J. Paul
• 87. Regulation of Smooth Muscle Contraction - Susanne Vetterkind and Kathleen G. Morgan
• Section B: Heterogeneities
• 88. Heterogeneity of Smooth Muscle - Richard Arnold/, Christine Chaponnier, Ciulio Gabbiani, and Boris Hinz
• 89. Microcirculation - William F Jackson
• 90. Uterine Smooth Muscle - Susan Wray and Sarah Arrowsmith
• Section C: Adaptations and Response
• 91. Oxidative Stress, Endothelial Dysfunction, and Its Impact on Smooth Muscle Signaling - Thomas Münzel and Tommaso Cori
• 92. Hemodynamic Control of Vascular Smooth Muscle Function - Eileen M. Redmond, Caitriona Lally and Paul A. Cahill
• 93. Myogenic Tone and Mecnanotransduction - Michael A. Hill and Gerald A. Meininger
• 94. Cell-Cell Communication Through Cap Junctions - Cor de Wit
• 95. Vascular Smooth Muscle Cell Phenotypic Adaptation - Joseph M. Miano
• 96. Molecular Pathways of Smooth Muscle Disease - Alejandra San Martin, Lula Hilenski, and Kathy K. Criendling
• Section D: Smooth Muscle Disease
• 97. Genetic Variants in Smooth Muscle Contraction and Adhesion Genes Cause Thoracic Aortic Aneurysms and Dissections and Other Vascular Diseases - Dianna M. Milewicz and Callie S. Kwartier
• 98. Vascular Smooth Muscle Cell Remodeling in Atherosclerosis and Restenosis - Elaine Smolock and Bradford C. Berk
• 99. Arterial Hypertension - Rhian M. Touyz and Ernesto L. Schiffrin
• 100. Diabetic Vascular Disease - Adam Whaley-Connell, Hanrui Zhang, Cuihua Zhang, and James R. Sowers
• 101. Vascular Mechanisms of Hypertension in the Pathophysiology of Preeclampsia - Eric M. George and Joey P. Granger
• 102. Erectile Dysfunction - Kelvin P. Davies
• 103. Smooth Muscle in the Normal and Diseased Pulmonary Circulation - Michael E. Yeager, Maria G. Frid Eva Nozik-Grayck, and Kurt R. Stenmark
• 104. Airway Smooth Muscle and Asthma - Susan J. Gunst
• 105. Aging - Luigi Giusto Spagnoli, Alessandro Mauriello, Augusto Orlandi, Manuel Scimeca, Antonio Volpe, and Elena Bonanno
• 106. Vascular Calcification - Linda Demer and Yin Tintut
• 107. Smooth Muscle Progenitor Cells: A Novel Target for the Treatment of Vascular Disease? - Andreas Schober, Zhou Zhe, and Christian Weber
• 108. Smooth Muscle: Novel Targets and Therapeutic Approaches - Mark W. Majesky
• Glossary