This multivolume reference work addresses the fact that the well being of humankind is predicated not only on individuals receiving adequate nutrition but also on their genetic makeup.

Table of Contents

• Preface
• About the Editors
• Contributors
• Part I Introductory Material and Foundations
• 1 Environmental Effects on Genomic Imprinting in Development and Disease - Rakesh Pathak and Robert Feil
• 2 Effect of Epigenetic Differences in Identical Twins - Tanya L. Schwab and Tara L. Hogenson
• 3 Nutrition, DNA Methylation, and Developmental Origins of Cardiometabolic Disease: A Signal Systems Approach - Zachary M. Laubach, Christopher D. Faulk, Andres Cardenas and Wei Perng
• 4 Folate and Epigenetics: Colorectal Cancer Risk and Detection - Nancy Lévesque, Daniel Leclerc and Rima Rozen
• 5 Epigenetics and the Microbiome - Meirav Pevsner-Fischer, Niv Zmora, Sofia Braverman and Eran Elinav
• 6 Implications of Genotype and Environment on Variation in DNA Methylation - Ives Y. Lim, Xinyi Lin and Neerja Karnani
• 7 Socioeconomics, Obesity, and Early-Life Nutrition on the Role of DNA Methylation in Biological Embedding - Christiana A. Demetriou, Karin van Veldhoven, Caroline Relton, Silvia Stringhini, Kyriacos Kyriacou and Paolo Vineis
• 8 Linking Enhancer to Epigenetics: New Way to Think About Human Diseases - Zhuojuan Luo and Chengqi Lin
• 9 Peroxisome Proliferator-Activated Receptor-Gamma Coactivator-1Alpha and DNA Methylation as Epigenetic Control - Xuemei Xie and Xiaoping Luo
• 10 Role of PIWI-Interacting RNA (piRNA) as Epigenetic Regulation - Danielle Queiroz Calcagno, Elizangela Rodrigues da Silva Mota, Fabiano Cordeiro Moreira, Stefanie Braga Maia de Sousa, Rommel Rodríguez Burbano and Paulo Pimentel Assumpção
• 11 Epigenetic Targeting of Vascular Endothelial Growth Factor (VEGF) Receptors - Steven G. Gray
• 12 Epigenetic Aspects of Nuclear Receptor Coregulators: How Nutritional and Environmental Signals Change Gene Expression Patterns - Fawaz Alzaïd, Tomas Jakobsson, Eckardt Treuter and Nicolas Venteclef
• 13 Diversity of Human CpG Islands - Isabel Mendizabal and Soojin V. Yi
• 14 DNA Demethylation and Epigenetics - Xiaofei Zhang, Thomas E. Witzig and Xiaosheng Wu
• 15 Guanine-Quadruplexes and Possible Role in Nutritional Epigenetics and Aging - Paniz Tavakoli, Wayne Leifert, Michael Fenech and Maxime François
• 16 Role of SIRT1 in Epigenetics - Zhipeng A. Wang, Willie Hsu and Wenshe R. Liu
• 17 The Epigenetically Modulated Circadian System: Implications for Nutrition and Health. Nutritional Modulation of the Circadian Epigenome - Lidia Daimiel
• 18 Epigenetic Regulation of Fat Deposition: A Focus on Krüppel-Like Factor 14 (Klf14) - Robert A. Koza
• 19 Regulatory Roles of PARP-1 and Lipids in Epigenetic Mechanisms - Maria Rosaria Faraone-Mennella, Annalisa Masi and Carla Ferreri
• 20 Methylation in CPT1A, Lipoproteins, and Epigenetics - Stella Aslibekyan and Steven A. Claas
• 21 Histone Deacetylase HDAC8 and Insulin Resistance - Vincent Wai-Sun Wong, Myth Tsz-Shun Mok and Alfred Sze-Lok Cheng
• 22 Prenatal Programming and Epigenetics of Obesity Metabolic Phenotype: Pre- and Postnatal Metabolic Phenotypes and Molecular Mechanisms - Antonio Gonzalez-Bulnes and Susana Astiz
• 23 Perinatal Malnutrition and Epigenetic Regulation of Long-Term Metabolism - Daniel B. Hardy
• 24 Epigenetics of Undernutrition - Omar Ramos-Lopez, Jose Ignacio Riezu-Boj, Fermin I. Milagro and J. Alfredo Martinez
• 25 Cancer Epigenomics on Precision Medicine and Immunotherapy - Javier I. J. Orozco, Diego M. Marzese and Dave S. B. Hoon
• 26 Epigenetics of Systemic Sclerosis - Nezam Altorok, Vivek Nagaraja and Bashar Kahaleh
• 27 Traces of Life's Experiences: Epigenetics (DNA methylation) in Forensics - Meenu Ghai, Dyfed Lloyd Evans and Shailesh Joshi
• 28 Epigenetics, Dietary Restriction, and Insects: Implications for Humankind - Ting Lian, Uma Gaur and Mingyao Yang
• 29 Nutritional Programming and Effect of Ancestor Diet in Birds - Mireille Morisson, Vincent Coustham, Laure Frésard, Anne Collin, Tatiana Zerjal, Sonia Métayer-Coustard, Loys Bodin, Francis Minvielle, Jean-Michel Brun and Frédérique Pitel
• Part II Organs, Disease, and Life Stages
• 30 Molecular Biology of Human Obesity: Nonepigenetics in Comparison with Epigenetic Processes - David Albuquerque, Licínio Manco and Clévio Nóbrega
• 31 Epigenetics in Hyperphagia - Minati Singh
• 32 Adipogenesis and Noncoding RNAs - Pang-Kuo Lo, Benjamin Wolfson and Qun Zhou
• 33 MicroRNA-Regulated Immune Cell Function in Obese Adipose Tissue - Beiyan Zhou, Wei Ying, Chuan Li and Anthony T. Vella
• 34 DNA/Histone Methylation and Adipocyte Differentiation: Applications to Obesity - Yangmian Yuan, Chengyu Liu, Danyang Wan, Kun Huang and Ling Zheng
• 35 Nutritional Programming of Metabolic Syndrome: Role of Nutrients in Shaping the Epigenetics - Sonal Patel, Arpankumar Choksi, Richa Pant, Aftab Alam and Samit Chattopadhyay
• 36 MicroRNAs in Metabolic Syndrome - Juan Francisco Codocedo and Nibaldo C. Inestrosa
• 37 Sperm Epigenome in Obesity - Nur Duale, Oliwia Witczak, Gunnar Brunborg, Trine B. Haugen and Birgitte Lindeman
• 38 Carbohydrate-Responsive Histone Acetylation in Gene Body Regions - Kazuki Mochizuki, Natsuyo Hariya, Kazue Honma and Toshinao Goda
• 39 Epigenetic and Metabolism: Glucose and Homeotic Transcription Factor PREP1 VRP Suggested Epigenetics and Metabolism - Luigi Albano, Paolo Emidio Macchia and Paola Ungaro
• 40 Impact of Epigenetic Mechanisms on the Regulation of Gene Expression During Intrauterine Programming of the Endocrine Pancreas - Ana Laura Ortega-Márquez, Angélica Morales-Miranda and Sumiko Morimoto
• 41 Butyrate, a Short-Chain Fatty Acid and Histone Deacetylases Inhibitor: Nutritional, Physiological, and Pharmacological Aspects in Diabetes - Sabbir Khan, Krishna Prahlad Maremanda and Gopabandhu Jena
• 42 Insulin Action, Insulin Resistance, and Their Link to Histone Acetylation - Aneta Balcerczyk, Sabrina Chriett and Luciano Pirola
• 43 Distribution of Methylated Regions Within gDNA in Acute and Chronic Phases of Diabetes Mellitus - Alexey A. Leontovich and Michael P. Sarras Jr.
• 44 Long-Term Complications in Diabetes Mellitus and the Interrelationship of Blood Vessel Formation, Endothelial Progenitor Cells, and gDNA Methylation - Michael P. Sarras Jr. and Alexey A. Leontovich
• 45 Epigenetics of Diabetic Nephropathy - Harvest F. Gu
• 46 Multiple miRNA Regulation of Lipoprotein Lipase - Sybil Charriere and Philippe Moulin
• 47 Nutritional Stress and Fetal Epigenetics in the Brain - Qingyi Ma and Lubo Zhang
• 48 Brain Hypothalamic Proopiomelanocortin and High-Fat Diet on Methylation in Offspring as Epigenetic Modifications - Jia Zheng and Xinhua Xiao
• 49 Epigenetic Effects of Nutrients Involved in Neurodevelopmental and Mental Disorders - Takeo Kubota and Kazuki Mochizuki
• 50 Psychosocial Impact of Epigenetics in Pediatrics - Xiaoming Gong and Lewis P. Rubin
• 51 MicroRNAs as Neuroregulators - Ketan S. Patil and Simon G. Møller
• 52 Diet, Epigenetics, and Alzheimer's Disease - Andrea Fuso and Cristina Domenichelli
• 53 Epigenetic Alterations in Stomach Cancer: Implications for Diet and Nutrition - Carolina Oliveira Gigek, Elizabeth Suchi Chen and Marilia Arruda Cardoso Smith
• 54 Epigenetics of Dietary Methyl-Group Donor Deficiency and Liver Cancer - Aline de Conti and Igor P. Pogribny
• 55 Nuclear Receptors and Epigenetic Regulation - Ornella I. Selmin, Alberto P. Romagnolo and Donato F. Romagnolo
• 56 Epigenetic Regulation of Early Nutrition on Immune System - Lorella Paparo, Rosita Aitoro, Rita Nocerino, Carmen di Scala, Margherita D. Costanzo, Linda Cosenza, Viviana Granata and Roberto Berni Canani
• 57 miRNAs and Their Role in the Pathogenesis of Celiac Disease: A Review - Donatella Barisani
• 58 Diet and Epigenetic Alteration of Renal Function - Eva Nüsken, Kai-Dietrich Nüsken and Jörg Dötsch
• 59 Liver Diseases: Epigenetic Mechanisms, Oxidative Stress, and Use of Alpha-Lipoic Acid - Aleksandra Uskoković, Svetlana Dinić, Jelena Arambašić Jovanović, Goran Poznanović, Melita Vidaković and Mirjana Mihailović
• 60 High-Fat Diet and Maternal Obesity-Associated Epigenetic Regulation of Bone Development - Jin-Ran Chen
• 61 Epigenetic Alterations in Human Sperm - Naoko Miyauchi, Akane Kitamura, Hitoshi Hiura, Hiroaki Okae, Norio Kobayashi, Hiromitsu Hattori, Souta Takahashi and Takahiro Arima
• 62 Gaps in Knowledge and Missing Evidence in the Role of DNA Methylation in Biological Embedding - Christiana A. Demetriou, Karin van Veldhoven, Caroline Relton, Silvia Stringhini, Kyriacos Kyriacou and Paolo Vineis
• 63 Interplay Between Maternal Micronutrients, DNA Methylation, and Brain Development - Richa Rathod and Sadhana Joshi
• 64 Gestational Betaine, Liver Metabolism, and Epigenetics - Demin Cai, Haoyu Liu, Yun Hu, Yuqian Jiang and Ruqian Zhao
• 65 Maternal Methyl Supplemented Diets and Epimutations in Offspring - Cheryl S. Rosenfeld
• 66 Epigenetic Consequences of Low Birth-Weight and Preterm Birth in Adult Twins - Qihua Tan
• 67 Influence of Maternal Nutrition on Genomic Imprinting and Fetal Growth - Emily Chapman, Jia Chen and Maya A. Deyssenroth
• 68 Epigenetic Mechanisms in Food Allergy - David J. Martino
• 69 Epigenetic Programming of Water Drinking and Sodium Intake - Andre Souza Mecawi, Michael Paul Greenwood and Juan Arguelles
• 70 Igf1 DNA Methylation, Epigenetics, and Low-Salt Diet in Fetal Programming - Flávia Ramos de Siqueira, Luzia Naôko Shinohara Furukawa and Joel Claudio Heimann
• 71 Preventing and Diagnosing Diabetic Complications: Epigenetics, miRNA, DNA Methylation, and Histone Modifications - Daoyin Dong, E. Albert Reece and Peixin Yang
• 72 Embryopathy as a Model for the Epigenetics Regulation of Complications in Diabetes - Daoyin Dong, E. Albert Reece and Peixin Yang
• 73 Slow Growth Period and Epigenetics - Lars Olov Bygren and Gunnar Kaati
• 74 Developmental Programming and Transgenerational Transmission of Obesity - Mark H. Vickers
• 75 Epigenetics and Aging - Carolina Soriano-Tárraga, Jordi Jiménez-Conde and Jaume Roquer
• Part III Influence of Diet and Nutrition on Epigenetics
• 76 Energy Metabolism and Epigenetics - Scott J. Bultman
• 77 Milk Exosomes and MicroRNAs: Potential Epigenetic Regulators - Bodo C. Melnik and Foteini Kakulas
• 78 Nutritional Regulation of Mammary miRNome: Implications for Human Studies - Christine Leroux, Dragan Milenkovic, Lenha Mobuchon, Sandrine L. Guillou, Yannick Faulconnier, Bruce German and Fabienne L. Provost
• 79 Diet-Induced Epigenetic Modifications and Implications for Intestinal Diseases - Elodie Gimier, Nicolas Barnich and Jérémy Denizot
• 80 Nutritional and Epigenetics Implications in Esophageal Cancer - Danielle Queiroz Calcagno, Kelly Cristina da Silva Oliveira and Nina Nayara Ferreira Martins
• 81 The Methyl-CpG-Binding Domain (MBD) Protein Family: An Overview and Dietary Influences - Carolina Oliveira Gigek, Elizabeth Suchi Chen, Gaspar Jesus Lopes-Filho and Marilia Arruda Cardoso Smith
• 82 Epigenetic Effects of N-3 Polyunsaturated Fatty Acids - Christine Heberden and Elise Maximin
• 83 Threonine Catabolism: An Unexpected Epigenetic Regulator of Mouse Embryonic Stem Cells - Ruta Jog, Guohua Chen, Todd Leff and Jian Wang
• 84 The Role and Epigenetic Modification of the Retinoic Acid Receptor - Yukihiko Kato
• 85 Histone Deacetylase Inhibitor Tributyrin and Vitamin A in Cancer - Renato Heidor, Ernesto Vargas-Mendez and Fernando Salvador Moreno
• 86 Association Between MicroRNA Expression and Vitamin C in Ovarian Cells - Yong Jin Kim, Yoon Young Kim and Seung-Yup Ku
• 87 Rewriting the Script: The Story of Vitamin C and the Epigenome - Tyler C. Huff and Gaofeng Wang
• 88 Vitamin C and DNA Demethylation in Regulatory T Cells - Varun Sasidharan Nair and Kwon I. Oh
• 89 Cobalamin, Microbiota and Epigenetics - Joan Jory
• 90 Maternal Folate and DNA Methylation in Offspring - Emma L. Beckett, Mark Lucock, Martin Veysey and Bonnie R. Joubert
• 91 Modulation of microRNA by Vitamin D in Cancer Studies - Emma L. Beckett, Martin Veysey, Zoe Yates and Mark Lucock
• 92 Epigenetics and Minerals: An Overview - Inga Wessels
• 93 Calcium-Deficient Diets in Pregnancy and Nursing: Epigenetic Change in Three Generations of Offspring - Junji Takaya
• 94 Selenoproteins and Epigenetic Regulation in Mammals - Hsin-Yi Lu, Berna Somuncu, Jianhong Zhu, Meltem Muftuoglu and Wen-Hsing Cheng
• 95 DNA Methylation in Anti-cancer Effects of Dietary Catechols and Stilbenoids: An Overview of Underlying Mechanisms - Megan Beetch and Barbara Stefanska
• 96 Epigenetic Drivers of Resveratrol-Induced Suppression of Mammary Carcinogenesis: Addressing miRNAs, Protein, mRNA, and DNA Methylation - E. R. Sauter
• 97 PARylation, DNA (De)methylation, and Diabetes - Melita Vidaković, Anja Tolić, Nevena Grdović, Mirunalini Ravichandran and Tomasz P. Jurkowski
• 98 Extra Virgin Olive Oil and Corn Oil and Epigenetic Patterns in Breast Cancer - Raquel Moral and Eduard Escrich
• 99 Natural Polyphenol Kaempferol and Its Epigenetic Impact on Histone Deacetylases: Focus on Human Liver Cells - Sascha Venturelli, Christian Leischner and Markus Burkard
• 100 Dietary Methylselenocysteine and Epigenetic Regulation of Circadian Gene Expression - Helmut Zarbl and Mingzhu Fang
• 101 Proanthocyanidins and Epigenetics - Cinta Bladé, Anna Arola-Arnal, Anna Crescenti, Manuel Suárez, Francisca I. Bravo, Gerard Aragonès, Begoña Muguerza and Lluís Arola
• 102 Application of Nutraceuticals in Pregnancy Complications: Does Epigenetics Play a Role? - Luís Fernando Schütz, Jomer Bernardo, Minh Le, Tincy Thomas, Chau Nguyen, Diana Zapata, Hitaji Sanford, John D. Bowman, Brett M. Mitchell and Mahua Choudhury
• 103 Polyphenols and Histone Acetylation - Anna K. Kiss
• 104 Ginkgo biloba, DNA Damage and DNA Repair: Overview - Daniela Oliveira, Bjorn Johansson and Rui Oliveira
• 105 Plant Monoterpenes Camphor, Eucalyptol, Thujone, and DNA Repair - Biljana Nikolić, Dragana Mitić-Ćulafić, Branka Vuković-Gačić and Jelena Knežević-Vukčević
• 106 Modulatory Role of Curcumin in miR-Mediated Regulation in Cancer and Non-cancer Diseases - Sayantani Chowdhury, Jyotirmoy Ghosh and Parames C. Sil
• 107 Epigenetic Impact of Indoles and Isothiocyanates on Cancer Prevention - Pushpinder Kaur and Jaspreet Kaur
• 108 Epigenetic Phenomena of Arsenic and Histone Tail Modifications: Implications for Diet and Nutrition - Qiao Y. Chen and Max Costa
• 109 Arsenic and microRNA Expression - Elena Sturchio, Miriam Zanellato, Priscilla Boccia, Claudia Meconi and Silvia Gioiosa
• 110 Epigenetic Effects of Bisphenol A (BPA): A Literature Review in the Context of Human Dietary Exposure - Luísa Camacho and Igor P. Pogribny
• 111 Ochratoxin A and Epigenetics - Alessandra Mezzelani
• 112 Silver and Histone Modifications - Yuko Ibuki
• 113 High-Fructose Consumption and the Epigenetics of DNA Methylation - Hiroya Yamada, Eiji Munetsuna and Koji Ohashi
• Part IV Practical Techniques and Applications
• 114 Multilocus Methylation Assays in Epigenetics - Thomas Eggermann
• 115 Illumina HumanMethylation BeadChip for Genome-Wide DNA Methylation Profiling: Advantages and Limitations - Kazuhiko Nakabayashi
• 116 Bioinformatics Databases and Tools on Dietary MicroRNA - Juan Cui
• 117 MicroRNAs and Reference Gene Methodology - Petra Matoušková
• 118 Mass Spectrometry and Epigenetics - Luciano Nicosia, Roberta Noberini, Monica Soldi, Alessandro Cuomo, Daniele Musiani, Valeria Spadotto and Tiziana Bonaldi
• 119 Forward and Reverse Epigenomics in Embryonic Stem Cells - Ilana Livyatan and Eran Meshorer
• 120 MiRImpact as a Methodological Tool for the Analysis of MicroRNA at the Level of Molecular Pathways - Anton A. Buzdin and Nikolay M. Borisov
• 121 Resources in Diet, Nutrition, and Epigenetics - Rajkumar Rajendram, Vinood B. Patel and Victor R. Preedy