Genetics and Genomics in Nursing and Health Care

Editor/Author Beery, Theresa A.
Publication Year: 2018
Publisher: F.A.Davis Company

ISBN: 978-0-8036-6083-0
Category: Health & Medicine - Nursing
Image Count: 122
Book Status: Pending
Predicted Release Month: March 2019
Table of Contents

Confidently tackle the basics of genetic inheritance, the influence of somatic and germline mutations, the multifactorial relationship of gene-environment interactions, and the foundation of ethical behavior. Everyday language makes these often-intimidating topics easy to understand, while clearly defined principles, logical explanations, illustrations, tables, and clinical examples ensure you master the material.

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Table of Contents

  • About the Authors
  • Preface
  • Reviewers
  • Acknowledgments
  • UNIT I Basic Concepts From Molecular Genetics
  • Chapter 1 DNA Structure and Function
  • Introduction
  • Genetic Biology
  • DNA
  • Chapter 2 Protein Synthesis
  • Introduction
  • Transcription
  • Translation
  • Mutations
  • Summary
  • Chapter 3 Genetic Influences on Cell Division, Cell Differentiation, and Gametogenesis
  • Introduction
  • Normal Cell Biology
  • Early Embryonic Cell Biology
  • Commitment and Differentiation
  • Gametogenesis
  • Summary
  • UNIT II Gene Expression
  • Chapter 4 Patterns of Inheritance
  • Introduction
  • Mendelian Inheritance
  • Punnett Square Analysis and Probability
  • Chromosomal Inheritance
  • Complex (Multifactorial) Disease
  • Genomic Variation Influencing Susceptibility and Resistance to Health Problems
  • Summary
  • Chapter 5 Epigenetic Influences on Gene Expression
  • Introduction
  • Microbiome
  • Epigenetics and Cancer
  • Nature and Nurture Working Together
  • The Future of Epigenetics: Are There Clinical Applications?
  • Chapter 6 Autosomal Inheritance and Disorders
  • Introduction
  • Chromosomal Inheritance
  • Common Chromosomal Disorders
  • Summary
  • Chapter 7 Sex Chromosome and Mitochondrial Inheritance and Disorders
  • Introduction
  • Extra X Chromosomes
  • Extra Y Chromosomes
  • Monosomy
  • Genotype-Phenotype Gender Mismatch
  • Fragile X Syndrome
  • Mitochondrial Gene Inheritance
  • Summary
  • Chapter 8 Family History and Pedigree Construction
  • Introduction
  • Family History
  • Pedigree Construction
  • Punnett Squares
  • Pedigree Analysis
  • Summary
  • Chapter 9 Congenital Anomalies, Basic Dysmorphology, and Genetic Assessment
  • Introduction
  • Major and Minor Anomalies
  • Classification of Congenital Anomalies
  • Syndrome or Sequence
  • Dysmorphology Assessment
  • Assessment Through a Genetic Lens
  • Summary
  • UNIT III Genomic Health Problems Across the Life Span
  • Chapter 10 Enzyme and Collagen Disorders
  • Introduction
  • Enzyme Disorders
  • Collagen Disorders
  • Summary
  • Chapter 11 Common Childhood-Onset Genetic Disorders
  • Introduction
  • Monogenic Disorders
  • Complex Disorders
  • Summary
  • Chapter 12 Common Adult-Onset Genetic Disorders
  • Introduction
  • Monogenic Disorders
  • Complex Disorders
  • Diseases Affecting Older Adults
  • Summary
  • UNIT IV Genomic Influences on Selected Complex Health Problems
  • Chapter 13 Cardiovascular Disorders
  • Introduction
  • Atherosclerosis and Coronary Artery Disease
  • Stroke
  • Hypertension
  • Arrhythmias
  • Cardiomyopathy
  • Summary
  • Chapter 14 The Genetics of Cancer
  • Introduction
  • Benign Tumor Cells
  • Cancer Cells
  • Cancer Development
  • Summary
  • Chapter 15 Genetic Contributions to Psychiatric and Behavioral Disorders
  • Introduction
  • Genetics Applications for the Psychiatric Patient
  • Autism
  • Attention-Deficit Hyperactivity Disorder
  • Schizophrenia
  • Affective Disorders
  • Substance Use Disorders
  • Personality Disorders
  • Summary
  • UNIT V Genomics and Disease Management
  • Chapter 16 Genetic and Genomic Testing
  • Introduction
  • Genetic Testing Samples
  • Types of Genetic Tests
  • Oversight of Genetic Testing
  • Laboratory Methods Used for Genetic Testing
  • Direct-to-Consumer Genetic Testing
  • Risks and Benefits of Genetic Testing
  • Summary
  • Chapter 17 Assessing Genomic Variation in Drug Response
  • Introduction
  • Pharmacodynamics
  • Pharmacokinetics
  • Genetic/Genomic Variations
  • Clinical Applications of Pharmacogenomics
  • Genetic Testing for Drug Response
  • Summary
  • Chapter 18 Health Professionals and Genomic Care
  • Introduction
  • Genetics Professionals
  • Role of General Nurses in Genomic Care
  • Interdisciplinary Health-Care Professionals
  • Summary
  • UNIT VI Global Genomic Issues
  • Chapter 19 Financial, Ethical, Legal, and Social Considerations
  • Introduction
  • Ethical Goals of Clinical Genetics
  • Genetic Discrimination
  • Duty to Warn Versus the Right to Privacy
  • Intellectual Property Rights and Gene Patents
  • Gene Therapy
  • Summary
  • Chapter 20 Genetic and Genomic Variation
  • Introduction
  • Population Genetics
  • Race, Ethnicity, and Human Genetic Variation
  • Summary
  • Appendix A Genetics Organizations and Support Groups
  • Appendix B Selected Educational Websites
  • Glossary