Handbook of Cannabis and Related Pathologies: Biology, Pharmacology, Diagnosis, and Treatment is the first book to take an interdisciplinary approach to the understanding of cannabis use and misuse.

Table of Contents

• List of Contributors
• Preface
• I Setting the Scene, Botanical, General and International Aspects
• The Cannabis Plant: Botanical Aspects
• The Biosynthesis of Cannabinoids
• Increasing Plant Concentrations of THC and Implications on Health Related Disorders
• Age as a Predictor of Cannabis Use
• Lifetime Cannabis Use and Cognition in Psychosis Spectrum Disorders
• A Profile of Synthetic Cannabinoid Users
• Dual Disorders in Cannabis Misuse
• Cannabis Use and Cognitive Function
• Cannabis, Migration, and Psychosis Onset
• The Global Epidemiology and Disease Burden of Cannabis Use and Dependence
• International Aspects of Cannabis Use and Misuse: the Australian Perspective
• International Aspects of Cannabis Use and Misuse: Egypt
• Cannabis Body Packing: A Caribbean Perspective
• Tetrahydrocannabinol Concentration and Genetic Characterization of Cannabis
• II Personal, Social and Community Aspects of Cannabis use
• Gender Differences in Cannabis Use Disorders
• The Role of Age in the Onset and Further Development of Cannabis Use Disorders
• Effects of Cannabis Use on Neurocognition in Adolescents and Emerging Adults
• Correlates and Consequences of Prenatal Cannabis Exposure (PCE): Identifying and Characterizing Vulnerable Maternal Populations and Determining Outcomes for Exposed Offspring
• Cannabis and Clubbing: Relevance of Cannabis and Polydrug Use in the Clubbing Culture Today
• Cannabis and Sexual Behavior
• Friendships and Cannabis Use
• Students’ Knowledge of Cannabis
• Childhood Trauma and Cannabis: Risk Factors in Severe Mental Disorders?
• Parent's Influence on Children's Cannabis Use
• Cannabis Users and Premorbid Intellectual Quotient
• Cannabis and Traffic Accidents
• Cannabis Use in Youth Subcultures
• III Cannabis, Behavior, Psychopathology and Neuropathology
• Drug-Related Pictures, Attentional Bias, and Cannabis Use
• Cannabis Use and First-Episode Psychosis Patients (FEP)
• Cannabis, Associative Memory, fMRI, and the Implicit Association Test
• Stress Response in Cannabis Users and Psychosis
• Motivation in Chronic Cannabis Use
• Cannabis Use and Its Association to Mental Illness: A Focus on Mood and Anxiety Disorders
• Cannabis Use and Well-Being
• Craving and Cannabis: A Potential Paradox
• Delta-9-Tetrahydrocannabinol and Catalepsy-Like Immobilization
• The Interactive Nature of Cannabis and Schizophrenia Risk Genes
• Neuroimaging Findings in Adolescent Cannabis Use and Early Phase Psychosis
• Cannabis Smoking in Adult Schizophrenia: A Cognitive and Functional Magnetic Resonance Imaging Perspective
• The Long-Lasting Effects of Cannabis Use on Movement and Brain Regions that Control Movement
• Assessment of Cannabis Acute Effects on Driving Skills: Laboratory, Simulator, and On-Road Studies
• Chronic Cannabis Use and Axonal Fiber Connectivity
• Microglial Activation and Cannabis Exposure
• Cannabis and Psychosis: Correlation, Causality, and Consequences
• Cannabis Use in Bipolar Disorder
• Cannabis Use in Epilepsy—Risks and Benefits
• Cannabis, Cannabinoids, and Visceral Pain
• Cannabis and Postoperative Analgesia
• Aggressive Behavior and Cannabis Use
• COMT Genotypes, Cannabis Use, and Psychosis: Gene-Environment Interaction Evidence from Human Populations, and Its Methodological Concerns
• Neuroimaging and Genetics of the Acute and Chronic Effects of Cannabis
• Gray Matter, Lateral Ventricle Volumes, and Executive Functioning in Cannabis Users with First-Episode Psychosis
• Cannabis Use and Attention-Deficit/Hyperactivity Disorder: Potential Moderators
• IV Cannabis, Organs, Tissues and Non-cns Aspects
• Chronic Cannabis Abuse and Thyroid Function
• Cannabis Hyperemesis Syndrome
• Cannabis and Cannabinoids and the Effects on Gastrointestinal Function: An Overview
• Cardiovascular Effects of Cannabis Usage
• Cannabis and Stroke
• Cannabis Smoking and the Lung
• Cannabis and Hepatic Injury
• Cannabis Allergy: More Than a Bad Trip
• Marijuana and Breastfeeding
• Hypocretins/Orexins and Addiction: Role in Cannabis Dependence
• Regulatory Role of Cannabinoids for Skin Barrier Functions and Cutaneous Inflammation
• Cannabis and Oral Health: Deleterious Effects on Periodontitis and Dental Implants
• Does Cannabis Use Increase the Risk of Developing Cancer in Humans?
• Cannabis and the Use of Amphetamine-Like Substances
• V Pharmacology and Cellular Activities of Cannabinoids and Endocannabinoids
• Cannabinoids and the Cannabinoid Receptors: An Overview
• Signaling and Regulation of the Cannabinoid CB1 Receptor
• Allosteric Modulation of the Cannabinoid CB1 Receptor
• Polymorphisms of the CB2 Cannabinoid Receptor
• Chemistry of Cannabinoid Receptor Agonists
• The Endocannabinoid System as a Target for New Antiseizure Drugs
• Pharmacological Aspects of Anandamide and 2-Arachidonoyglycerol as Bioactive Lipids
• Pharmacological Aspects of NMDA Receptors, mGluR5, and Endocannabinoids
• Peripheral CB1 Receptors and Ghrelin in Feeding Regulation: Pharmacological Implications
• Pharmacological Aspects of Novel Antiobesity Agents Related to Cannabinoids
• Cannabinoid Reward and Dependence: Focus on the Main Psychoactive Ingredients of Marijuana in Preclinical Studies
• Peroxisome Proliferator Activated Receptors and Cannabinoids
• The Protein–Protein Interactions of Cannabinoid Receptor Interacting Protein 1a (CRIP1a) and Cannabinoid 1 Receptor: The Molecular Mechanism Study Through an Integrated Molecular Modeling Approach
• Synthetic Cannabinoids: a Summary of Selected Phenomena With Respect to Behavioral Pharmacology and Abuse Liability
• Cannabinoid Signaling in Glioma Cells and Therapeutic implications
• VI Effects of Specific Natural and Synthetic Cannabinoids
• The Role of 5-HT1A Receptor, and Nausea and Vomiting Relief by Cannabidiol (CBD), Cannabidiolic Acid (CBDA), and Cannabigerol (CBG)
• Genetic and Molecular Aspects of Addiction with Tetrahydrocannabinol
• Effects of Δ9-Tetrahydrocannabinol in Human Breast Cancer
• Δ9-THC and COX-2 Signaling
• Cannabinoids and the Addictive Effects of Nicotine
• Cannabinoid Regulation of Intraocular Pressure: Human and Animal Studies, Cellular and Molecular Targets
• Ocular Delivery of Tetrahydrocannabinol
• The Role of γ-Aminobutyric Acid in the Interoceptive Effects of Oral Δ9-Tetrahydrocannabinol in Humans
• The Role of Δ9-Tetrahydrocannabinol in Diabetes Mellitus
• Cannabidiol: An Overview of its Antipsychotic Properties
• Cannabidiol for the Treatment of Epilepsy: An Overview of Possible Mechanisms of Action and Preclinical and Human Studies
• Cannabidiol and Neuroprotection: Evidence from Preclinical Studies
• Cannabinoids as Potent Inhibitors of Human CYP1 Enzymes
• The Synthetic Analog of Δ9-Tetrahydrocannabinol (THC): Nabilone. Pharmacology and Clinical Application
• Synthetic Cannabinoids in Dementia
• Synthetic Cannabinoid Receptor Agonists (Spice) as New Recreational Psychoactive Substances
• Accidents and Synthetic Cannabinoids in Blood of Drivers
• Cannabidiol as an Antioxidant
• The Anxiolytic Effects of Cannabidiol (CBD)
• New Ethological and Morphological Perspectives for the Investigation of Panicolytic-Like Effects of Cannabidiol
• Spice Use Among United States Military Personnel
• VII Medicinal Cannabis use
• Cannabis and Synthetic Cannabinoids for Cancer Patients: Multiple Palliative Indications Together With Promising Laboratory Antineoplastic Effects
• The Use of Medical Marijuana in the Treatment of Psychiatric Disorders
• Beneficial Effects of Cannabis and Related Compounds on Sleep
• Cannabinoid-Based Medicines for the Treatment of Gilles de la Tourette Syndrome
• Cannabidiol and Multiple Sclerosis
• Cannabinoids and Their Effects on Painful Neuropathy
• Cannabis for Basal Ganglia Disorders (Parkinson Disease and Huntington Disease)
• Medical Cannabis for the Treatment of Inflammatory Bowel Disease
• Cannabidiol for the Treatment of Drug Use Disorders
• Cannabinoids and Effects on the Gastrointestinal Tract: A Focus on Motility
• Potential Medical Uses of Cannabigerol: A Brief Overview
• Cannabis Use in Fibromyalgia
• VIII Screening, Diagnosis, and Treatment
• The Cannabis Abuse Screening Test (CAST) and Its Applications
• Screening of Synthetic Cannabinoids
• On-Site Drug Testing for Cannabis
• Cannabinoids in Oral Fluid: Identification and Interpretation of Analytical Results
• Cannabinoids in Exhaled Breath
• Barriers to Treatment Seeking for Cannabis Dependence
• Pharmacotherapies for Cannabis Use Disorders
• Self-Initiated Cannabis Use Cessation in Adolescents and Emerging Adults
• Treating Cannabis-Dependent Adolescents with Family Therapy: The case of Multidimensional Family Therapy
• Cognitive Behavioral Therapy in Cannabis Use Disorder
• The Cannabis Withdrawal Syndrome— Symptoms and Time Course
• School-Based Cannabis Prevention Programs
• The CapOpus Trial for Cannabis Use Disorders
• Treating Cannabis Use Disorders Through Technology-Assisted Interventions: the Telephone and Internet
• Reducing Cannabis Use With a Real-Time Intervention Using Mobile Technology
• Short Instruments to Screen for “Problematic” Cannabis Use in General Population Surveys
• Self-report of Cannabis Use
• CANDIS Program: Modular Treatment of Cannabis Use Disorders
• Engaging Cannabis Users in Treatment
• Cannabis Neuropathology Resources and Recommended Reading