An Introduction to Pain and its relation to Nervous System Disorders

Editor/Author Battaglia, Anna A.
Publication Year: 2016
Publisher: Wiley

Single-User Purchase Price: $180.00
Unlimited-User Purchase Price: $270.00
ISBN: 978-1-118-45591-3
Category: Health & Medicine - Medicine
Image Count: 45
Book Status: Available
Table of Contents

Introduction to Pain and its relation to Nervous System Disorders provides an accessible overview of the latest developments in the science underpinning pain research, including, but not limited to, the physiological, pathological and psychological aspects. This unique book fills a gap in current literature by focussing on the intricate relationship between pain and human nervous system disorders such as Autism, Alzheimer Disease, Parkinson's Disease, Depression and Multiple Sclerosis.

Share this

Table of Contents

  • List of Tables
  • List of Illustrations
  • Cover Image Legends
  • Dedication
  • List of contributors
  • Foreword
  • Acknowledgements
  • Notes on authors
  • Introduction
  • What is pain?
  • Aims
  • Summary of contributions
  • References
  • SECTION I: Neurobiology of pain
  • CHAPTER 1: Anatomy of pain pathways
  • Basic organisation of spinal pain pathways
  • Primary afferent input to the dorsal horn
  • Projection neurons and ascending tracts
  • Dorsal horn interneurons
  • Descending pathways
  • Neuronal circuits
  • Future directions
  • References
  • CHAPTER 2: Spinal plasticity of the nociceptive system
  • Introduction
  • Nociceptive pain and nociception
  • Mechanisms of central sensitisation
  • Central sensitisation in pathological states
  • Other diseases with chronic pain syndromes
  • Concluding remarks
  • Acknowledgements
  • References
  • CHAPTER 3: Symptoms and pathology in neuropathic pain
  • Introduction
  • Defining and diagnosing neuropathic pain
  • Epidemiology and management
  • Sensory signs and symptoms
  • Physiology and pathophysiology in neuropathic pain
  • Peripheral pathology in neuropathic pain
  • Central pathology in neuropathic pain
  • Roles of the immune system in neuropathic pain
  • Conclusion
  • References
  • CHAPTER 4: Recent advances in neuroimmune interactions in neuropathic pain
  • Introduction
  • Chronic neuropathic pain
  • Concluding remarks
  • References
  • CHAPTER 5: Genetics and epigenetics of pain
  • Genetics: Introduction
  • Genetics of chronic pain
  • Epigenetics: Introduction
  • Epigenetics in chronic pain
  • References
  • CHAPTER 6: The cannabinoid system and its role in nociception
  • A brief history of cannabis
  • Discovery of the endocannabinoid system
  • Cannabinoid receptor intracellular signalling
  • Endocannabinoids synthesis and degradation
  • Pharmacological tools for investigating the endocannabinoid system
  • Cannabinoids and nociception
  • Which cannabinoid for which pain
  • Conclusions and perspectives
  • Acknowledgements
  • References
  • CHAPTER 7: EphB receptors and persistent pain
  • A brief introduction to Eph receptors and their ligands, the ephrins
  • Ephb receptors and hypersensitivity in inflammatory and neuropathic pain
  • Ephb receptors in visceral and cancer pain
  • Ephb receptors and morphine tolerance
  • A few open questions
  • Potential for translation
  • Overview
  • References
  • SECTION II: Pain in the brain
  • CHAPTER 8: Brain imaging in experimental pain
  • Brain-imaging methods
  • Brain imaging of experimental acute pain
  • Salience, pain and specificity
  • Concluding remarks
  • References
  • CHAPTER 9: Placebo effects in pain
  • Introduction
  • Definitions
  • Psychological mechanisms
  • Neurobiological mechanisms
  • Clinical implications
  • Controversy
  • Acknowledgements
  • References
  • CHAPTER 10: Psychology and pain
  • Introduction
  • Pain experiences and physical causation
  • ‘Nocebo’: An interesting example of pain appearing without a painful stimulus
  • Pain defined
  • The impact of chronic pain
  • The gate control theory of pain
  • Psychosocial approaches to treatment for pain
  • The fear–avoidance model of chronic pain
  • The newest model of pain and suffering: Psychological flexibility
  • Evidence for CBT, ACT, and multidimensional approaches to chronic pain
  • The role of psychology in the outcome of treatment trials
  • Treatment mechanisms in chronic pain
  • Summary
  • References
  • SECTION III: Pain in the lifecycle and in nervous system disorders
  • CHAPTER 11: Pain in neonates and infants
  • Infant pain assessment
  • Infant pain management
  • Long-term consequences of pain in early life
  • Ethical implications of pain in neonates
  • Pain research
  • References
  • CHAPTER 12: How do people with autism spectrum disorders (ASD) experience pain?
  • Introduction
  • Pain and autism: Review of the literature
  • Main theories about pain in autism
  • How to assess pain in people with communicativeand social deficits
  • How to manage and treat pain in this population
  • Pain and autism: An integrated model
  • Conclusion
  • References
  • CHAPTER 13: Pain and depression
  • Introduction
  • The ache and depression: A close encounter in the past centuries
  • The psychoanalytical theory of ache
  • A necessary point of view on DSM-5: A new approach to somatic symptoms?
  • Chronic pain and depression
  • The concept of mental pain
  • Neuroplasticity in pain, mood and depression
  • Chronic pain and mood disorders as a maladaptation of the reward system
  • Antidepressants as ‘analgesic’
  • References
  • CHAPTER 14: Pain in multiple sclerosis
  • Introduction
  • Classification of pain syndromes
  • Prevalence of pain in MS
  • Pathophysiology of major pain symptoms in MS
  • Treatment of central neuropathic pain
  • Musculoskeletal pain
  • Secondary pain
  • Conclusions
  • References
  • CHAPTER 15: Pain perception in dementia
  • Introduction
  • Experimental perspective
  • Clinical perspective
  • Overall conclusion
  • Acknowledgement
  • References
  • CHAPTER 16: The role of cognitive impairment in the placebo and nocebo effects
  • Introduction
  • References
  • CHAPTER 17: An overview of pain in Parkinson's disease
  • Introduction
  • Definition of pain
  • Pathogenesis
  • Pain as a premotor and presenting symptom in PD
  • Epidemiology
  • Systems of classification of pain in PD
  • Description of pain in PD
  • Assessment scales
  • Treament
  • References
  • APPENDIX: Interviews with chronic pain patients