Posttraumatic Stress Disorder: From Neurobiology to Treatment

Editor/Author Bremner, J. Douglas
Publication Year: 2016
Publisher: Wiley

Single-User Purchase Price: $130.00 This title is available for purchase on Credo platforms only. This is not a download.
Unlimited-User Purchase Price: $195.00
ISBN: 978-1-118-35611-1
Category: Psychology
Image Count: 42
Book Status: Available
Table of Contents

Posttraumatic Stress Disorder: From Neurobiology to Treatment presents a comprehensive look at this key neuropsychiatric disorder. The text examines the neurobiological basis of post-traumatic stress and how our understanding of the basic elements of the disease have informed and been translated into new and existing treatment options.

This book is found in the following Credo Collections:

Psychology Essentials Collection

List of Illustrations
List of Tables
List of contributors
Introduction
Reference
Section I: Preclinical sciences of stress
Chapter 1: Posttraumatic stress disorder: from neurobiology to clinical presentation
1.1 PTSD: prevalence, risk factors, and etiology
1.2 Neurobiology of PTSD
1.3 Synthesis of findings: from neurobiology to treatment of PTSD
References
Chapter 2: The epidemiology of posttraumatic stress disorder in children and adolescents: a critical review
2.1 Introduction
2.2 Studies involving general population surveys
2.3 Prevalence of exposure to traumatic events in youth populations
2.4 Community surveys assessing child-adolescent PTSD prevalence
2.5 Childhood/adolescent PTSD rates according to type of trauma
2.6 Child-adolescent PTSD and comorbid disorders
2.7 Risk factors associated with child-adolescent PTSD
2.8 Summary
2.9 Acknowledgement
References
Chapter 3: Early life stress and development: preclinical science
3.1 Overview
3.2 Early life stress and the hypothalamic–pituitary–adrenal (HPA) axis
3.3 Rodent models of early life stress/trauma
3.4 Non-human primate models of early life stress/trauma
3.5 Impact of early life stress on prefrontal-limbic brain circuits across species: biological and evolutionary mechanisms
3.6 Conclusions
3.7 Acknowledgements
References
Chapter 4: Amygdala contributions to fear and safety conditioning: insights into PTSD from an animal model across development
4.1 Introduction
4.2 Stress and defensive responding
4.3 Fear conditioning
4.4 Safety conditioning
4.5 Ontogeny of fear and safety conditioning
4.6 Implications for PTSD
4.7 Conclusion
4.8 Acknowledgement
References
Chapter 5: Preclinical evidence for benzodiazepine receptor involvement in the pathophysiology of PTSD, comorbid substance abuse, and alcoholism
5.1 Introduction
5.2 Stress and the Benzodiazepine Receptor
5.3 Interaction of Stress, Alcohol Intake and the Benzodiazepine Rector
5.4 Stress, Drug Abuse and the Benzodiazepine Receptor
5.5 Translation from Neurobiology to PTSD
5.6 Conclusions
References
Chapter 6: Psychosocial predator stress model of PTSD based on clinically relevant risk factors for trauma-induced psychopathology
6.1 Introduction
6.2 General characteristics of PTSD
6.3 Preclinical models of PTSD
6.4 Psychosocial predator stress model of PTSD
6.5 Summary: the challenge of modeling PTSD in animals
6.6 Acknowledgements
References
Chapter 7: Coping with stress in wild birds – the evolutionary foundations of stress responses
7.1 Introduction
7.2 Physiological changes associated with chronic stress in wild birds
7.3 Lessons from wild birds
7.4 Conclusions
7.5 Acknowledgements
References
Chapter 8: Stress, fear, and memory in healthy individuals
8.1 Introduction
8.2 Time-dependent effects of stress on episodic memory in healthy humans
8.3 Stress and fear conditioning in humans
8.4 Stress-induced modulation of multiple memory systems
8.5 Stress and memory in healthy subjects: implications for PTSD
References
Section II: Neurobiology of PTSD
Chapter 9: Neurotransmitter, neurohormonal, and neuropeptidal function in stress and PTSD
9.1 Introduction
9.2 Noradrenergic system
9.3 HPA axis
9.4 PTSD and inflammation
9.5 Acetylcholine and vagal nerve function
9.6 Dopaminergic system
9.7 NMDA
9.8 Serotonin
9.9 GABA/benzodiazepine system
9.10 Opioid peptides
9.11 Neurotensin
9.12 Somatostatin
9.13 Cholecystokinin
9.14 Neuropeptide Y
9.15 Galanin
9.16 Ghrelin
9.17 Substance P
9.18 Vasoactive intestinal peptide
9.19 Vasopressin and oxytocin
9.20 Neurosteroids and neurohormones
9.21 Conclusions
References
Chapter 10: Genomics of PTSD
10.1 Introduction
10.2 Genetic studies in PTSD
10.3 Gene–environment interaction studies in PTSD
10.4 Epigenetic and gene expression studies in PTSD
10.5 Conclusions
References
Chapter 11: Cortisol and the Hypothalamic–Pituitary–Adrenal Axis in PTSD
11.1 Introduction
11.2 HPA axis and the stress response
11.3 HPA axis alterations in PTSD
11.4 HPA feedback functioning and GR sensitivity
11.5 Gender, PTSD, and HPA axis activity
11.6 HPA alterations as a risk factor for PTSD
11.7 Genetic and epigenetic influences on GR sensitivity
11.8 Modifying glucocorticoid responsiveness: implications for prevention and treatment
11.9 Conclusion
References
Chapter 12: Neuroimaging of PTSD
12.1 History and background
12.2 Neural circuits of PTSD
12.3 Changes in brain structure and cognitive functioning in PTSD
12.4 Neurohormonal responses to PTSD
12.5 Functional neuroimaging studies in PTSD
12.6 Neuroreceptor Studies in PTSD
12.7 Conclusions
References
Section III: PTSD and co-occuring conditions
Chapter 13: PTSD and mild traumatic brain injury
13.1 Introduction
13.2 Mild TBI
13.3 Posttraumatic stress disorder
13.4 Overlap between mTBI and PTSD
13.5 Summary and conclusions
References
Chapter 14: Stress-related psychopathology and pain
14.1 Introduction
14.2 Depression
14.3 Schizophrenia
14.4 Anorexia nervosa
14.5 Borderline personality disorder
14.6 Post-traumatic stress disorder
14.7 Conclusion
References
Chapter 15: Stress and health
15.1 Introduction
15.2 Stress and cardiovascular disease
15.3 Depression and cardiovascular disease
15.4 PTSD and cardiovascular disease
15.5 Potential mechanisms linking stress to cardiovascular disease
15.6 Mechanisms through which depression and PTSD may increase CVD risk
15.7 Stress, PTSD and functional pain disorders
15.8 Conclusions
References
Section IV: PTSD: from neurobiology to treatment
Chapter 16: Pharmacotherapy for PTSD: effects on PTSD symptoms and the brain
16.1 Introduction
16.2 Agents acting on the GABA–benzodiazepine receptor complex
16.3 Agents acting on norepinephrine and serotonin receptors
16.4 Tricyclic and monoamine oxidase inhibitor antidepressants
16.5 Medications with other mechanisms of action
16.6 Selective norepinephrine reuptake inhibitors
16.7 Selective serotonin reuptake inhibitors
16.8 Antidepressants with actions on norepinephrine and epinephrine reuptake
16.9 Mood stabilizers
16.10 Antipsychotic medications
16.11 Glutamatergic agents
16.12 MDMA
16.13 Effect of pharmacotherapy on the brain and neurobiology in PTSD
16.14 Conclusions
References
Chapter 17: Effects of psychotherapy for psychological trauma on PTSD symptoms and the brain
17.1 Psychotherapy for psychological trauma
17.2 The neuroscience of early interventions for trauma
17.3 Psychological therapy for psychological trauma
17.4 Effects of psychotherapy on the brain
17.5 Brain imaging of psychotherapy in PTSD
17.6 Conclusions
References