Kucers The Use of Antibiotics is the definitive, internationally-authored reference, providing everything that the infectious diseases specialist and prescriber needs to know about antimicrobials in this vast and rapidly developing field. The much-expanded Seventh Edition covers all new and existing therapies, and emerging drugs not yet fully licensed.

Table of Contents

• Contributors
• Foreword to the 7th Edition
• Foreword to the 6th Edition
• Obituary
• Hail the Greats
• Preface
• Abbreviations
• VOLUME 1
• Section 1 INTRODUCTION
• 1 Principles of Antimicrobial Use
• 2 Use of Critically Important Antimicrobials in Food Production
• Section 2 ANTIBIOTICS
• PART 2:1 PENICILLINS AND RELATED DRUGS
• 3 Benzylpenicillin (Penicillin G)
• 4 Phenoxypenicillins
• 5 Ampicillin and Amoxicillin
• 6 Methicillin
• 7 Isoxazolyl Penicillins: Oxacillin, Cloxacillin, Dicloxacillin, and Flucloxacillin
• 8 Nafcillin
• 9 Carbenicillin, Carindacillin, Carfecillin, and Ticarcillin
• 10 Mezlocillin, Azlocillin, Apalcillin, and Piperacillin
• 11 Mecillinam (Amdinocillin) and Pivmecillinam
• 12 Temocillin
• 13 Beta-Lactamase Inhibitors
• 14 Amoxicillin–Clavulanic Acid
• 15 Ampicillin–Sulbactam
• 16 Ticarcillin–Clavulanic Acid
• 17 Piperacillin–Tazobactam
• PART 2:2 CEPHALOSPORINS AND RELATED DRUGS
• 18 Cephalothin and Cefazolin
• 19 Cephalexin
• 20 Cephadroxil, Cephaloridine, Cephacetrile, Cephapirin, Cephradine, and Other Rarely Used First-Generation Cephalosporins
• 21 Cefaclor, Cefprozil, and Loracarbef
• 22 Cefuroxime
• 23 Cefotiam, Cefuzonam, Cefamandole, Cefonicid, and Ceforanide
• 24 Cefoxitin, Cefotetan, and Other Cephamycins
• 25 Cefoperazone and Cefoperazone–Sulbactam
• 26 Cefotaxime
• 27 Ceftriaxone
• 28 Ceftizoxime, Cefdinir, Cefditoren, Cefpodoxime, Ceftibuten, Cefsulodin, and Cefpiramide
• 29 Cefixime
• 30 Ceftazidime and Ceftazidime–Avibactam
• 31 Cefepime, Cefpirome, and Cefepime–Tazobactam
• 32 Ceftaroline and Ceftaroline–Avibactam
• 33 Ceftobiprole
• 34 Ceftolozane–Tazobactam
• 35 Aztreonam and Aztreonam–Avibactam
• 36 Cefiderocol (S-649266)
• PART 2:3 CARBAPENEMS
• 37 Imipenem–Cilastatin and Imipenem–Relebactam
• 38 Meropenem and Meropenem–Vaborbactam
• 39 Doripenem
• 40 Ertapenem
• 41 Faropenem
• 42 Biapenem, Ritipenem, Panipenem, and Sulopenem
• PART 2:4 GLYCOPEPTIDES AND LIPOPEPTIDES
• 43 Vancomycin
• 44 Teicoplanin
• 45 Daptomycin
• 46 Oritavancin
• 47 Dalbavancin
• 48 Telavancin
• 49 Ramoplanin
• 50 Surotomycin
• PART 2:5 AMINOGLYCOSIDES
• 51 Kanamycin
• 52 Gentamicin
• 53 Tobramycin
• 54 Amikacin
• 55 Sisomicin and Netilmicin
• 56 Isepamicin
• 57 Neomycin
• 58 Plazomicin
• PART 2:6 MACROLIDES AND KETOLIDES
• 59 Erythromycin
• 60 Roxithromycin
• 61 Clarithromycin
• 62 Azithromycin
• 63 Josamycin and Rosaramicin
• 64 Telithromycin
• 65 Cethromycin
• 66 Solithromycin
• PART 2:7 TETRACYCLINES AND RELATED DRUGS
• 67 Tetracycline
• 68 Doxycycline
• 69 Minocycline
• 70 Tigecycline
• 71 Omadacycline
• 72 Eravacycline
• PART 2:8 OTHER ANTIBIOTICS
• 73 Linezolid
• 74 Cadazolid
• 75 Radezolid
• 76 Tedizolid
• 77 Quinupristin–Dalfopristin
• 78 Pristinamycin
• 79 Fosfomycin
• 80 Fusidate Sodium
• 81 Polymyxins
• 82 Novobiocin
• 83 Bacitracin and Gramicidin
• 84 Mupirocin
• 85 Clindamycin and Lincomycin
• 86 Chloramphenicol and Thiamphenicol
• 87 Spectinomycin
• 88 Fidaxomicin
• 89 Lefamulin
• 90 Retapamulin
• PART 2:9 ANTIFOLATE AGENTS AND OTHER SYNTHETIC ANTIBACTERIALS
• 91 Sulfonamides
• 92 Trimethoprim and Trimethoprim–Sulfamethoxazole (Cotrimoxazole)
• 93 Pyrimethamine
• 94 Dapsone
• 95 Trimetrexate
• 96 Iclaprim
• 97 Nitrofurans: Nitrofurazone, Furazidine, and Nitrofurantoin
• 98 Methenamine Mandelate and Methenamine Hippurate
• PART 2:10 NITROIMIDAZOLES
• 99 Metronidazole
• 100 Tinidazole
• PART 2:11 QUINOLONES AND FLUOROQUINOLONES
• 2:11A NEW AND COMMONLY USED FLUOROQUINOLONES
• 101 Ciprofloxacin
• 102 Norfloxacin
• 103 Ofloxacin
• 104 Levofloxacin
• 105 Moxifloxacin
• 106 Gemifloxacin
• 107 Sitafloxacin
• 108 Delafloxacin
• 109 Finafloxacin
• 110 Prulifloxacin/Ulifloxacin
• 111 Avarofloxacin, Nemonoxacin, and Zabofloxacin
• 2:11B OLDER, RARELY USED QUINOLONES AND FLUOROQUINOLONES
• 112 Enoxacin
• 113 Fleroxacin
• 114 Garenoxacin
• 115 Gatifloxacin
• 116 Lomefloxacin
• 117 Nalidixic Acid and Other Quinolones
• 118 Pefloxacin
• 119 Rufloxacin
• 120 Sparfloxacin
• 121 Tosufloxacin
• 122 Discontinued Fluoroquinolones
• PART 2:12 ANTI-TUBERCULOUS DRUGS
• 123 Isoniazid
• 124 Ethambutol
• 125 Pyrazinamide
• 126 Rifampicin (Rifampin)
• 127 Rifabutin
• 128 Rifaximin
• 129 Rifapentine
• 130 Streptomycin
• 131 para-Aminosalicylic Acid (PAS)
• 132 Ethionamide and Prothionamide
• 133 Thiacetazone
• 134 Capreomycin
• 135 Cycloserine and Terizidone
• 136 Viomycin
• 137 Clofazimine
• 138 Bedaquiline
• 139 Delamanid and Pretomanid
• 140 Sutezolid
• Section 3 ANTIFUNGAL DRUGS
• PART 3:1 POLYENES
• 141 Amphotericin B Deoxycholate
• 142 Liposomal Amphotericin B
• 143 Amphotericin B Lipid Complex (ABLC)
• 144 Nystatin
• 145 Natamycin
• PART 3:2 ECHINOCANDINS
• 146 Caspofungin
• 147 Micafungin
• 148 Anidulafungin
• PART 3:3 ALLYLAMINES AND BENZYLAMINE DERIVATIVES
• 149 Terbinafine
• 150 Butenafine
• 151 Naftifine
• PART 3:4 SYSTEMIC AZOLES
• 152 Ketoconazole
• 153 Fluconazole
• 154 Itraconazole
• 155 Miconazole
• 156 Voriconazole
• 157 Posaconazole
• 158 Isavuconazole
• 159 Albaconazole
• 160 Ravuconazole
• PART 3:5 TOPICAL AZOLES
• 161 Topical Azoles
• PART 3:6 TOPICAL AGENTS—THIOCARBOMATES, HYDROXYPYRIDONES, AND MORPHOLINE
• 162 Tolnaftate
• 163 Amorolfine
• 164 Ciclopirox
• 165 Rilopirox
• PART 3:7 OTHER ANTIFUNGAL AGENTS
• 166 Flucytosine (5-Fluorocytosine; 5-FC)
• 167 Griseofulvin
• 168 Haloprogin
• VOLUME 3
• Section 4 ANTIPARASITIC DRUGS
• PART 4:1 ANTI-MALARIAL DRUGS
• 169 Artemisinins
• 170 Artesunate
• 171 Artemether–Lumefantrine
• 172 Dihydroartemisinin–Piperaquine
• 173 Pyronaridine–Artesunate
• 174 Artemisinin–Naphthoquine
• 175 Chloroquine and Hydroxychloroquine
• 176 Amodiaquine
• 177 Quinine and Quinidine
• 178 Mefloquine
• 179 Halofantrine
• 180 Primaquine
• 181 Tafenoquine
• 182 Atovaquone
• 183 Proguanil and Chlorproguanil
• 184 Atovaquone–Proguanil
• PART 4:2 AGENTS ACTIVE AGAINST INTESTINAL AND EXTRA-INTESTINAL PROTOZOA
• 185 Paromomycin
• 186 Nitazoxanide
• 187 Spiramycin
• 188 Fumagillin
• 189 Furazolidone (Furazolidine)
• 190 Diloxanide Furoate
• 191 Iodoquinol and Quinacrine
• PART 4:3 AGENTS ACTIVE AGAINST AMERICAN TRYPANOSOMIASIS
• 192 Benznidazole
• 193 Nifurtimox
• PART 4:4 AGENTS ACTIVE AGAINST AFRICAN TRYPANOSOMIASIS
• 194 Suramin
• 195 Melarsoprol
• 196 Eflornithine
• PART 4:5 AGENTS ACTIVE AGAINST LEISHMANIA AND OTHER PATHOGENS
• 197 Pentamidine
• 198 Antimonial Agents
• 199 Miltefosine
• PART 4:6 AGENTS ACTIVE AGAINST HELMINTHS
• 200 Albendazole
• 201 Mebendazole
• 202 Thiabendazole and Flubendazole
• 203 Triclabendazole
• 204 Ivermectin and Moxidectin
• 205 Diethylcarbamazine
• 206 Pyrantel and Oxantel Pamoate
• 207 Praziquantel
• 208 Oxamniquine and Metrifonate
• 209 Niclosamide
• PART 4:7 AGENTS ACTIVE AGAINST ECTOPARASITES
• 210 Permethrin
• 211 Lindane and Malathion
• 212 Crotamiton
• Section 5 ANTIVIRAL DRUGS
• PART 5:1 AGENTS ACTIVE AGAINST HERPESVIRUSES
• 213 Aciclovir and Valaciclovir
• 214 Famciclovir and Penciclovir
• 215 Ganciclovir and Valganciclovir
• 216 Cidofovir and Brincidofovir
• 217 Brivudin
• 218 Discontinued Herpesvirus Agent: Vidarabine
• 219 Foscarnet
• 220 Letermovir
• 221 Trifluridine (Trifluorothymidine)
• 222 Idoxuridine
• 223 Maribavir
• 224 Fomivirsen
• PART 5:2 AGENTS ACTIVE AGAINST THE HUMAN IMMUNODEFICIENCY VIRUS
• 5:2A NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS
• 225 Zidovudine
• 226 Didanosine
• 227 Zalcitabine
• 228 Lamivudine
• 229 Stavudine
• 230 Abacavir
• 231 Emtricitabine
• 232 Tenofovir
• 233 Amdoxovir
• 234 Apricitabine
• 5:2B NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS
• 235 Nevirapine
• 236 Efavirenz
• 237 Delavirdine
• 238 Etravirine
• 239 Rilpivirine
• 5:2C INHIBITORS OF HIV PROTEASE
• 240 Saquinavir
• 241 Indinavir
• 242 Nelfinavir
• 243 Lopinavir
• 244 Fosamprenavir
• 245 Darunavir
• 246 Atazanavir
• 247 Tipranavir
• 248 Ritonavir and Cobicistat
• 5:2D INTEGRASE INHIBITORS
• 249 Raltegravir
• 250 Elvitegravir
• 251 Dolutegravir
• 5:2E OTHER ANTI-HIV AGENTS
• 252 Enfuvirtide
• 253 Maraviroc
• PART 5:3 AGENTS ACTIVE AGAINST HEPATITIS VIRUSES
• 254 Entecavir
• 255 Adefovir Dipivoxil
• 256 Telbivudine
• 257 Discontinued Hepatitis Agents: Torcitabine and Valtorcitabine
• 258 Discontinued Hepatitis Agent: Clevudine
• 259 Ribavirin
• 260 Interferon Alpha
• 261 Protease, Polymerase and Assembly Inhibitors for the Treatment of Hepatitis C Virus Infection
• 262 Sofosbuvir Combined with Ledipasvir, Daclatasvir, or Other Drugs
• 263 Ombitasvir Combined with Paritaprevir, Dasabuvir, or Other Drugs
• 264 Grazoprevir Combined with Elbasvir or Other Drugs
• PART 5:4 AGENTS ACTIVE AGAINST INFLUENZA VIRUSES
• 265 Amantadine and Rimantadine
• 266 Zanamivir, Laninamivir, and Polyvalent Zanamivir Conjugates
• 267 Oseltamivir
• 268 Peramivir
• PART 5:5 INVESTIGATIONAL ANTIVIRAL DRUGS
• 269 Investigational Antiviral Drugs