This Handbook is an excellent reference text for the growing number of academics, students, scientists and practitioners in the drug and alcohol studies community, and will be a vital resource to the allied professions involved in work-place drug testing, clinical toxicology, and forensic science.

Table of Contents

• Editorial Board
• List of Figures
• List of Tables
• Notes on the Editors and Contributors
• Introduction
• PART I DETERMINATION OF SUBSTANCE MISUSE
• 1 Genetics and Genomics in Addiction Research - Rohit Jaibhagwan Lodhi, David Rossolatos and Katherine Jean Aitchison
• 2 Basic Pharmacokinetics of Substance Misuse - Kim Wolff
• 3 Future Directions: The Role of Pharmacogenomics - Jason White and Andrew A. Somogyi
• PART II PK AND PD IN RELATION TO PATTERNS OF USE
• 4 Alcohol: Pharmacokinetics and Pharmacodynamics - Matthew Goldin and E. Jane Marshall
• 5 Nicotine: The Pharmacokinetics of Nicotine and Cotinine - Noorzurani Robson
• 6 Opioids: A Discussion of Pharmacokinetics and Pharmacodynamics in Those Who Misuse Drugs - Verena E. Metz and Sandra D. Comer
• 7 Cocaine: Pharmacokinetics, Pharmacodynamics and Addictive Potential - Glenn J. H. Dumont
• 8 Amphetamine & Methamphetamine: Pharmacokinetics and Pharmacodynamics - Kim P. C. Kuypers, Eef L. Theunissen and Johannes G. Ramaekers
• 9 MDMA: Pharmacokinetics - Magí Farré, Esther Papaseit and Rafael de la Torre
• 10 Benzodiazepines: A Discussion of Pharmacokinetic and Pharmacodynamic Effects - Alyson Bond and Malcolm Lader
• 11 Ketamine: The Pharmacokinetics and Pharmacodynamics in Misusing Populations - Kim Wolff
• 12 Cannabis: The Pharmacokinetics and Pharmacodynamics of Recreational and Medicinal Cannabis - David J. Allsop, Richard Kevin and Jonathon Arnold
• 13 Synthetic Cannabinoids: The Pharmacokinetics and Pharmacodynamics of Spice and Other Synthetic Cannabinoids - Aarti Gupta and Deepak Cyril D'Souza
• 14 Khat, Mephedrone and MDPV: Pharmacokinetic and Pharmacodynamic Parameters - Manuel Ruiz and Lorenza Colzato
• 15 Gamma-hydroxybutyric Acid and its Analogues: Pharmocokinetics and Pharmacodynamics - John B. Saunders, Jason P. Connor and Gerald F. X. Feeney
• 16 Polysubstance Use - Jason P. Connor, Gerald F. X. Feeney, Adrian B. Kelly and John B. Saunders
• PART III DETECTION AND TREATMENT OF DRUG AND ALCOHOL USE
• 17 A Brief Overview of the Detection of Drug and Alcohol Use: The Matching of Purposes and Procedures - Kim Wolff and Michael Gossop
• 18 Biomarkers of Alcohol Misuse - Natalie E. Walsham and Roy A. Sherwood
• 19 Treatment of Opioid Dependence - Kim Wolff, Steven Karch and Jason White
• 20 Wastewater Analysis for the Measurement of Population Level Drug Use: Sewage-Based Epidemiology - Bram Miserez and Alexander L. N. van Nuijs
• PART IV SPECIAL SETTINGS
• 21 Forensic Toxicology and Death Investigation - A. Robert W. Forrest
• 22 Alcohol-related Offences, Alcohol Use Disorders and the Workplace - Kim Wolff, Samantha Gross, Noorzurani Robson and E. Jane Marshall
• 23 Future Directions: What is the Way Forward for Toxicology and Forensic Research? - Steven Karch
• PART V CONTROVERSIES AND NEW APPROACHES
• 24 Intravenous Abuse of Methylphenidate - Bjarni O. Rafnar and Gudrun Dora Bjarnadottir
• 25 Non Addictive Drug Use: The Way Forward - Christian P. Müller
• 26 Different Approaches to Setting Limits for Drugs and Alcohol Use When Driving - Kim Wolff
• 27 Where do Gambling and Internet ‘Addictions’ Belong? The Status of ‘Other’ Addictions - Mark D. Griffiths, Daria J. Kuss, Halley M. Pontes and Joël Billieux
• 28 Emerging Tobacco Trends from the Arabian Cultures (Waterpipe and Dokha): Global Prevalence, Health Risks and Propensity for Abuse - Annie Crookes
• 29 Treating Benzodiazepine Dependence – Abstinence or Maintenance? - Deborah Zador
• 30 ADHD: Pathways into Addiction, Diagnosis and Pharmacotherapy - Pieter-Jan Carpentier, Philip Asherson and Ulrich Müller
• 31 Exploratory Models to Explain Attention Deficit Hyperactivity Disorder and its Association with Substance Use - Susan Young and Ottilie Sedgwick