Encyclopedia of Immunobiology
Encyclopedia of Immunobiology
Editor: Ratcliffe, Michael
Publication Year: 2016
Publisher: Elsevier Science & Technology
Single-User Purchase Price:
$2940.00

Unlimited-User Purchase Price:
$4410.00
ISBN: 978-0-12-374279-7
Category: Science - Biology
Image Count:
801
Book Status: Available
Table of Contents
As the largest integrated source of immunological knowledge currently available, Encyclopedia of Immunobiology is a go-to reference for students and professionals alike, providing relevant topics to those working on experimental and clinical immunology, microbiology, biochemistry, genetics, veterinary science, physiology, and hematology.
Table of Contents
- Editor in Chief
- Volume Editors
- Guide to Using the Encyclopedia
- Preface
- Permission Acknowledgments
- Volume 1 Development and Phylogeny of the Immune System
- Myeloid and B Cell Development
- Ontogeny of the Hematopoietic System
- Adult Hematopoiesis
- Myelopoiesis
- Molecular Mechanisms of Stable Lineage Identity in Early B-Lymphocyte Development
- Fetal B Cell Development
- B-1 B Cell Development
- Pre-BCR
- Regulation of Igh Recombination and Allelic Exclusion
- Regulation of IgL Chain Recombination
- Central B Cell Tolerance
- Mechanisms of Peripheral B Cell Tolerance
- BAFF and B Cell Development, Homeostasis, and Selection
- Marginal Zone B Cell Development
- Human B Cell Development and Tolerance
- Human B Cell Subsets
- B Cell Development in Birds
- B Cell Development in Mucosa-Associated Lymphoid Tissues
- Development of T Cells and Innate Lymphoid Cells
- Development of Natural Killer Cells and ILC1
- Development of Group 2 Innate Lymphoid Cells
- Innate Lymphoid Cells Type 3
- Development of Thymic Epithelial Cells
- Notch Functions in T Cell Development
- Orchestration of T Cell Development by Common γ Chain Cytokines
- Transcriptional Regulation of T Cell Lineage Commitment
- Transcriptional and Microenvironmental Regulation of γδ T Cell Development
- Production of the Semi-Invariant TCR and PLZF Function in Innate Programming of iNKT Cells
- CD4/CD8 Lineage Commitment
- Control of Early T Cell Development by Notch and T Cell Receptor Signals
- TCR Affinity and Signaling during Thymocyte Selection
- Control of Migration during Intrathymic T Cell Development
- Thymocyte–mTEC Cross Talk for Self-Tolerance in T Cells
- Development of Regulatory T Cells in the Thymus
- DN TCRαβ Intraepithelial T Cell Development in the Thymus
- Cells of the Innate Immune System
- Neutrophils – Role in Innate Immunity
- Macrophage Activation and Polarization
- Kupffer Cells in Immunity
- Microglia – Role in Immunity
- Mast Cells in Allergy, Host Defense, and Immune Regulation
- Basophils – Role in Immunity
- Eosinophils
- Dendritic Cells and Dendritic Cell Subsets
- Natural Killer Cells
- The Role of Invariant NKT Cells in Immunity
- Polymorphic KIR-HLA System Regulates Natural Killer Cell Response
- ILC2 in Immunity
- Phylogeny of the Immune System
- Defense Mechanisms in Plants
- Emergence of Immune System Components in Cnidarians
- Molecular Evolution of Defense Pathways in Sponges: Self–Self-recognition and Fight against the Nonself
- Immunity in Molluscs
- The Immune System of Crustaceans
- Immunity in Insects
- The Immune System of Echinoderms
- The Immune System of Agnathans (Jawless Vertebrates)
- The Immune System and Immunity in Cartilaginous Fish
- The Immune System of Bony Fish
- The Immune System of Amphibians
- The Immune System in Reptiles
- The Avian Immune System
- The Immune System of Monotremes and Marsupials
- The Immune System of Lagomorphs
- The Immune System of Sheep and Goats
- The Immune System of Cattle
- The Immune System of Swine
- The Immune System of Horses and Other Equids
- Volume 2 Molecular Immunology
- Structure and Function of Diversifying Receptors
- Structure, Function, and Production of Immunoglobulin M (IgM)
- IgG Structure and Function
- Structure and Function of IgA
- Structure and Function of IgE
- Structure, Function, and Spatial Organization of the B Cell Receptor
- Genomic Organization of the Murine and Human IGH Locus
- Genomic Organization of Murine and Human Immunoglobulin Light Chain Loci
- Structure and Function of TCRαβ Receptors
- Structure and Function of TCRγδ Receptors
- Organization and Rearrangement of TCR Loci
- The Role of RAG in V(D)J Recombination
- NHEJ and Other Repair Factors in V(D)J Recombination
- AID in Somatic Hypermutation and Class Switch Recombination
- Error-Prone Mismatch and Base Excision DNA Repair in Somatic Hypermutation
- DNA Repair during Class Switch Recombination
- Immunoglobulin Diversification by Gene Conversion
- Variable Lymphocyte Receptors: The Basis of Adaptive Immunity in Jawless Vertebrates
- Structure and Function of Camelid VHH
- Structure and Function of IgNARS in Sharks and Other Cartilaginous Fish
- MHC Structure and Function
- Genetics and Genomic Organization of the Major Histocompatibility Complex (MHC)
- Structure of Classical Class I MHC Molecules
- Structure of Nonclassical MHC I (HLA-E, HLA-F, HLA-G, and Orthologs)
- Structure of Classical MHCII (HLA-DP, DQ, DR, and Orthologs)
- Repertoire of Classical MHC Class I and Class II Molecules
- The Peptide Ligands Presented by MHC Class II Molecules
- Repertoire of Nonclassical MHC I (HLA-E, HLA-F, HLA-G, and Orthologues)
- Immune Epitope Database and Analysis Resource
- Origin and Processing of MHC-I Ligands
- Ligand Selection and Trafficking for MHC I
- Origin and Processing of MHC Class II Ligands
- Ligand Selection and Trafficking for MHC II
- Cluster of Differentiation 1 (CD1): A Family of Lipid Antigen-Presenting Molecules
- MR1 (in Mouse and Man)
- Structures and Functions of MHC-like Proteins
- Molecular Immunoevasion Strategies Targeting Antigen Processing and Presentation
- HLA and Autoimmunity
- Genetic Associations of the Major Histocompatibility Complex (MHC) with Infectious Disease
- HLA and Drug Hypersensitivity
- Molecular Aspects of Innate Immunity
- Classical Complement Pathway
- Alternative Pathway of Complement
- Inflammatory Products of the Complement Pathway
- Proteolytic Cascades
- The NOD-Like Receptors
- Cytoplasmic Viral RNA Sensors: RIG-I-Like Receptors
- Fc Receptors and Fc Receptor-Like Molecules within the Immunoreceptor Family
- Scavenger Receptors
- The Mucins
- Peptidoglycan Recognition Proteins and Lysozyme
- Regulation of Immune Cell Functions through Nectin and Nectin-Like Receptors
- SLAM Family Receptors
- Ectonucleotidases in Immunobiology
- Neuroendocrine Peptides
- Cytokines and their Receptors
- The Interleukin-1 Family
- Inflammasomes
- Roles of TNF and Other Members of the TNF Family in the Regulation of Innate Immunity
- Lymphotoxin
- The Biology of Interleukin-6, a Major Target in Anti-Inflammatory Therapies
- Interferon α/β
- Interferon γ: An Overview of Its Functions in Health and Disease
- New Interferons
- γc Family Cytokines: Role in Immune Cell Development and Function
- The Cellular and Molecular Network of IL-4 and IL-13
- The IL-12/IL-23 Cytokine Family
- Interleukin-17 Family
- IL-10
- The IL-20 Subfamily of Cytokines and Their Receptors
- TGFβ
- Function of Chemokines and Their Receptors in Immunity
- Atypical Chemokine Receptors
- Colony Stimulating Factors (CSFs)
- Viral Anticytokine Strategies
- Volume 3 Activation of the Immune System
- Signal Transduction
- TCR Signaling: Proximal Signaling
- Adapter Molecules in Immune Receptor Signaling
- Immunological Synapses
- Kinase and Phosphatase Effector Pathways in T Cells
- Cellular Metabolism Controls Lymphocyte Activation and Differentiation
- Signal Transduction by the B Cell Antigen Receptor
- Ubiquitin Signaling to NF-κB
- Chemokine Receptor Signaling
- Integrins: Regulation of Adhesion and Downstream Signaling
- Signaling of Phagocytosis
- Control of Cell Survival and Apoptosis
- Signaling Pathways Downstream of TLRs and IL-1 Family Receptors
- TNF Receptor Superfamily Signaling Pathways in Immune Cells
- Structural Biology of JAK/STAT Cytokines and Their Receptors
- Jak-STAT Signaling Pathways
- Nuclear Receptors in Immune Function
- B Cell Activation
- Antigen Acquisition In Vivo and its Role in B Cell Activation
- Regulation of B Cell Migration and Location in Response to Antigens
- T Cell–Dependent B Cell Activation
- Germinal Centers
- Somatic Hypermutation and Class Switch Recombination
- Memory B Cells
- Long-Lived Plasma Cells
- Extrafollicular Antibody Responses
- Marginal Zone B Cell Responses to Antigens
- The Humoral Immune Response to T Cell–Independent Antigens
- Activation of B-1 Cells
- Cytokine Regulation of B Cell Activation and Differentiation
- B Cell–Associated Surface Molecules and B Cell Responses
- TNF and TNFR Family Members and B Cell Activation
- Cytokine-Producing Effector B Cells
- Vaccines to Program Protective Humoral Immunity
- B Cell Leukemia and Lymphoma
- T Cell Activation
- Th1 Cells
- The Differentiation and Function of Th2 and Th9 Cells
- Th17 and Th22 Cells
- Treg Cells
- γδ T Cell Functions and Biology
- Modification of T Cell Functions at Sites of Infection and Inflammation
- Recirculating and Resident Memory CD8+ T Cells
- Transition of T Cells from Effector to Memory Phase
- Cytotoxic Lymphocytes
- Conventional Dendritic Cells: Identification, Subsets, Development, and Functions
- Single T Cell Potential
- Anatomy and Microanatomy of the Immune System
- Thymic Microenvironments: Development, Organization, and Function
- Structure and Function of the Bone Marrow Hematopoietic Niche
- The Spleen
- Lymph Node Structure
- Anatomy and Microanatomy of Tonsils
- Anatomy and Function of the Gut Immune System
- Microanatomy and Immunity in the Liver
- Skin Immune System: Microanatomy
- Airway Immune System: Microanatomy
- Central Nervous System: Microanatomy
- Stromal Cells in Secondary Lymphoid Organs
- Tertiary Lymphoid Tissues
- Lymphocyte Recirculation
- Effector T Lymphocyte Migration to and Within Non-Lymphoid Tissues
- Leukocyte Adhesion Molecules
- Blood Vascular Endothelial Adhesion Molecules
- Endothelial Adhesion Molecules in the Lymphatic Vasculature
- Roles of Chemokines in Immune Cell Trafficking to Lymphoid Tissues
- S1P and LPA: Regulators of Immune Cell Egress and Ingress in Lymphoid Tissues
- Volume 4 Immunity to Pathogens and Tumors
- Immunity to Bacterial, Parasitic and Fungal Infections
- Immunology of Bacterial and Parasitic Diseases: An Overview
- Immunogenetics of Parasitic and Bacterial Disease
- Immune-Driven Pathogen Evolution
- Immunology of Tuberculosis
- Systems Immunology: Approaches to Tuberculosis
- Immunity to Enteropathogenic Escherichia coli
- Immunity to Salmonella
- Pneumococcal Biology, Diversity, Evolution and Host Responses to Infection
- Immunology of Bacterial Biodefense Agents: Francisella tularensis, Burkholderia mallei, and Yersinia pestis
- Immunology of Fungal Infections
- Subverting Immunity from the Inside: Strategies of Intracellular Survival – Protozoans
- Malaria, Immunity, and Immunopathology
- Immunology of African Trypanosomiasis
- Immunity to Trypanosoma cruzi
- Immunology of Leishmaniasis
- Toxoplasma gondii: Immune Protection and Evasion
- Immunity to Intestinal Protozoa: Entamoeba, Cryptosporidium, and Giardia
- Immunology of Lymphatic Filariasis
- Immunology of Schistosomiasis
- Immunology in Cestode Infections
- The Hygiene Hypothesis and Immunity to Parasitic Helminths
- Immunology of Central Nervous System Pathogens
- Immunology of Prion Disease
- Immunity to Viral Infections
- Sensors of Viral Infection
- Dendritic Cells in Viral Infection
- Innate Cytokine Responses and Their Functions during Viral Infections
- Intrinsic Cellular Defenses (TRIMS) in Modulating Viral Infection and Immunity
- NK Cells in Antiviral Defense
- NK Cells in T Cell Regulation
- NK Cells in HIV-1 Infection
- Chemokines and Viral Infections
- Antibody Responses and Functions in Defense against Viral Infection
- Activation of CD8 T Lymphocytes during Viral Infections
- CD4 T Cell Immunity to Viral Infection
- CD8 T Cell Memory to Pathogens
- Protective and Pathogenic T Cell Responses to Virus Infections
- T Cell Responses during Acute Respiratory Virus Infection
- Immune Responses to Viruses in the CNS
- Immunity to HIV
- Ebola Virus
- Immunity to Oncogenic Viruses
- Human Genetic Defects Resulting in Increased Susceptibility to Viral Infections
- Vaccination against Viruses
- Tumor Immunology
- Cancer Immunosurveillance: Immunoediting
- Inflammation and Cancer
- Tumor Antigens, Viral Origin
- Stem Cell Antigens in Cancer
- Personalized Immunotherapy Targeting the Cancer Mutanome
- CD8 T Lymphocytes in Antitumor Immunity
- CD4 T Cells in Antitumor Immunity
- Regulatory T Cells in Tumor Immunity
- NKT Cells in Tumor Immunity
- B Cells and Regulatory B Cells in Cancer Escape
- NK Cells in Antitumor Immunity
- Tumor-Associated Macrophages
- Dendritic Cells in the Tumor Microenvironment
- Immune Suppressive Myeloid-Derived Suppressor Cells in Cancer
- Soluble Mediators of Immune Suppression in the Tumor Microenvironment
- Vaccines and Their Role in CD8 T Cell-Mediated Antitumor Immunity
- Therapeutic and Prophylactic Cancer Vaccines
- Antibody Therapy
- From Adoptive Immunity to CAR Therapy: An Evolutionary Perspective
- Combining Immunotherapies with Standard Therapies in the Treatment of Cancer
- Volume 5 Physiology and Immune System Dysfunction
- Physiology of the Immune System
- The Intestinal Immune System
- Immunology of the Liver
- Immunology of the Eye
- Immunology of the Skin
- The Immunology of Adipose Tissue
- Immunology of the Testis and Privileged Sites
- Immunology of the Brain
- Immunology of the Female Reproductive Mucosa
- Immunity and the Endocrine System
- Effect of Sex on Cellular Immunity
- Effect of Sex on Humoral and Innate Immunity
- Neonatal Immunity
- Role of the Microbiota in Immune Development
- Immunity and Nutrition: the Role of Vitamins
- Immunity and Aging
- Autoimmunity
- Complex Genetic Control of Autoimmune Disease
- Autoimmune Diseases Arising out of Single Gene Defects
- Autoimmune Thyroid Disease
- Type 1 Diabetes
- Myasthenia Gravis
- The Immunobiology of Multiple Sclerosis
- Psoriasis, Cutaneous Lupus Erithematosus and Immunobiology of the Skin
- Systemic Lupus Erythematosus
- Rheumatoid Arthritis
- The Immune Responses of Celiac Disease
- Animal Models of Autoimmunity
- Transplantation
- Immune Tolerance in Hemopoietic Stem Cell Transplantation
- Transplantation Immunology: Kidney and Liver
- The Immunology of Pancreas Transplantation
- Animal Models of Transplantation
- Mesenchymal Stem Cells and Regenerative Medicine
- Allergy
- Allergens
- Allergic Contact Dermatitis: Immune Reactions in the Skin
- The Immunobiology of Asthma
- Immunology of Nasal Polyposis and Allergic Rhinitis
- Allergen Immunotherapy
- Biologicals to Treat Allergy and Asthma
- The Hygiene Hypothesis of Allergy and Asthma
- Microbiome and Allergy
- Immune Deficiency
- Primary Immunodeficiencies: Clinical and Biological Guidelines
- Thymus Abnormalities: DiGeorge Syndrome and Winged Helix Deficiency
- Combined T Cell and B Cell Deficiency – SCID Forms: T−B+
- Severe Combined Immune Deficiency with Absence of B and T Lymphocytes (T−B−NK+SCIDs): The Key Function of V(D)J Recombination for Lymphocyte Development
- Major Histocompatibility Complex Class II Deficiency
- Defects in T Cell Activation and Signaling
- Familial Lymphohistiocytosis
- Mendelian Susceptibility to Infections with Viruses, Mycobacteria, Bacteria, and Candida
- Wiskott–Aldrich Syndrome, Leukocyte Adhesion Deficiency, and Other Migration Defects in Human Primary Immunodeficiency
- Apoptosis-Related Autoimmune Lymphoproliferative Syndrome
- Autoimmune Polyendocrinopathy–Candidiasis–Ectodermal Dystrophy (APECED)
- Immunodysregulation, Polyendocrinopathy, and Enteropathy, X-Linked (IPEX) Syndrome
- The Immunologic Complications and Genetic Origins of Telomere Disorders
- Defects in B Cell Development
- Defects in B Cell Survival and Activation
- Immunoglobulin Class-Switch Recombination Defects
- Chronic Granulomatous Disease
- Monogenic Autoinflammatory Diseases
- Clinical Significance of Complement Abnormalities
- Principles of Treatment of Primary Immunodeficiencies
- Author Index