Encyclopedia of Cell Biology

Editors: Bradshaw, Ralph A. and Stahl, Philip D.
Publication Year: 2015
Publisher: Elsevier Science & Technology

Single-User Purchase Price: $2520.00
Unlimited-User Purchase Price: $3780.00
ISBN: 978-0-12-394447-4
Category: Science - Biology
Image Count: 1816
Video Count: 27
Book Status: Available
Table of Contents

The Encyclopedia of Cell Biology offers a broad overview of cell biology, offering reputable, foundational content for researchers and students across the biological and medical sciences.

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Table of Contents

  • Dedication
  • Editors-in-Chief
  • Volume Editors
  • Section Editors
  • Preface
  • Cell Biology: An Overview
  • Permission Acknowledgments
  • Volume 1: Molecular Cell Biology
  • Molecular Cell Biology: An Overview
  • MOLECULAR PRINCIPLES, COMPONENTS, TECHNOLOGY, AND CONCEPTS
  • BASIC PRINCIPLES
  • Chemical and Physical Principles
  • Biocatalysis
  • NUCLEIC ACIDS
  • DNA, RNA Chemical Properties (Including Sequencing and Next-Generation Sequencing)
  • The Chemical Synthesis of DNA and RNA Oligonucleotides for Drug Development and Synthetic Biology Applications
  • PROTEINS
  • Expression Systems
  • Isolation/Purification of Proteins
  • Protein Sequence Determination: Methodology and Evolutionary Implications
  • Posttranslational Modifications: Key Players in Health and Disease
  • Protein Domains: Structure, Function, and Methods
  • NMR in Structural and Cell Biology
  • Proteins: Folding, Misfolding, Disordered Proteins, and Related Diseases
  • Diseases of Protein Folding: Huntington’s Disease and Amyotrophic Lateral Sclerosis
  • Site-Directed Mutagenesis
  • Chemical Biology
  • Drug Design
  • Antibodies and Improved Engineered Formats (as Reagents)
  • LIPIDS
  • Lipidomics
  • Synthesis and Structure of Glycerolipids
  • Cholesterol and Other Steroids
  • Glycolipids
  • Lipid Signaling
  • MEMBRANES
  • Composition, Physical Properties, and Curvature
  • Lipid Rafts/Membrane Rafts
  • Membrane Potential: Concepts
  • The Outer Mitochondrial Membrane, a Smooth ‘Coat’ with Many Holes and Many Roles: Preparation, Protein Components, Interactions with Other Membranes, Involvement in Health, Disease, and as a Drug Target
  • Neuronal Action Potentials and Ion Channel Allostery
  • Cystic Fibrosis
  • CARBOHYDRATES
  • Glycogen and Starch
  • Proteoglycans
  • Hyaluronan
  • METABOLISM
  • Metabolic Regulation
  • A Structure Perspective on Organelle Bioenergetics
  • NUCLEIC ACID SYNTHESIS/BREAKDOWN
  • RNA SYNTHESIS/FUNCTION
  • Transfer RNA
  • Messenger RNA (mRNA): The Link between DNA and Protein
  • The Interplay between Eukaryotic mRNA Degradation and Translation
  • miRNAs/Small Noncoding RNAs
  • Small RNAs/Cancer
  • Riboswitches and Ribozymes
  • Ribosomal RNAs and Protein Synthesis
  • Comparison of Bacterial and Eukaryotic Replisome Components
  • DNA SYNTHESIS/REPAIR
  • Telomeres and Telomerase
  • Telomere Biology
  • Eukaryotic Nucleotide Excision Repair
  • The Base Excision Repair Pathway
  • Nonhomologous DNA End Joining
  • DNA Repair by Homologous Recombination
  • TRANSCRIPTION
  • Prokaryotic Transcription
  • Eukaryotic Transcriptional Regulation
  • Distant Activation of Transcription by Enhancers
  • The Spliceosome and Pre-mRNA Splicing
  • Pre-mRNA Splicing: Function and Dysfunction
  • NUCLEIC ACID TECHNOLOGY
  • Transgenesis and Gene Replacement
  • Viral Nucleic Acids
  • PROTEIN SYNTHESIS/DEGRADATION
  • TRANSLATION
  • Components, Initiation, Elongation, Termination, and Regulation
  • Biogenesis of Secretory Proteins
  • The Protein Biosynthetic Machinery of Mitochondria
  • Regulated Proteolysis of Signaling Molecules: The Proprotein Convertases
  • PROTEIN DEGRADATION – GENERAL
  • Mass Spectrometry-based Methodologies for Studying Proteolytic Networks and the Degradome
  • PROTEIN DEGRADATION – INTRACELLULAR
  • Ubiquitin, Ubiquitin-Like Proteins, and Proteasome-Mediated Degradation
  • Endoplasmic Reticulum-Associated Degradation and Protein Quality Control
  • Role of Lysosomes in Intracellular Degradation
  • PROTEIN DEGRADATION – PROTEASE CLASSES
  • Matrix Metalloproteinases
  • ADAMTS Proteases: Mediators of Physiological and Pathogenic Extracellular Proteolysis
  • ADAMs Regulate Cell–Cell Interactions by Controlling the Function of the EGF-Receptor, TNFα and Notch
  • Extracellular: Plasma Membrane Proteases – Serine Proteases
  • Aspartic Proteases of Alzheimer’s Disease: β- and γ-Secretases
  • The Calpain Proteolytic System
  • Cathepsin E: An Aspartic Protease with Diverse Functions and Biomedical Implications
  • Metalloproteases Meprin α and Meprin β in Health and Disease
  • Kallikrein
  • Naturally-Occurring Polypeptide Inhibitors: Cystatins/Stefins, Inhibitors of Apoptosis (IAPs), Serpins, and Tissue Inhibitors of Metalloproteinases (TIMPs)
  • PROTEOLYTIC PATHWAYS
  • Overview of Blood Coagulation and the Pathophysiology of Blood Coagulation Disorders
  • Molecular Mechanisms Underlying the Actions of the Complement System
  • Digestive Proteases: Roles in the Human Alimentary Tract
  • PROTEIN DEGRADATION – PATHOLOGICAL ASPECTS
  • Inhibitors of HIV Protease
  • Blood Pressure, Proteases and Inhibitors
  • Cancer – Proteases in the Progression and Metastasis
  • Lysosomal Diseases
  • Alpha-1-Antitrypsin Deficiency: A Misfolded Secretory Glycoprotein Damages the Liver by Proteotoxicity and Its Reduced Secretion Predisposes to Emphysematous Lung Disease Because of Protease-Inhibitor Imbalance
  • Volume 2: Organizational Cell Biology
  • Organizational Cell Biology: An Overview
  • IMAGING THE CELL
  • ELECTRON MICROSCOPY
  • Single-Particle CryoEM of Macromolecular Complexes
  • Scanning Electron Microscopy in Cell Biology
  • Electron Tomography
  • Immunoelectron Microscopy: High-Resolution Immunocytochemistry
  • Imaging Cellular Architecture with 3D SEM
  • LIGHT MICROSCOPY
  • Genetically Encoded Fluorescent Probes and Live Cell Imaging
  • Total Internal Reflection Fluorescence Microscopy
  • Super Resolution Fluorescence Localization Microscopy
  • Super-Resolution Light Microscopy: Stimulated Emission Depletion and Ground-State Depletion
  • Structured Illumination Microscopy
  • Fluorescence Correlation Spectroscopy: A Tool for Measuring Dynamic and Equilibrium Properties of Molecules in Cells
  • Fluorescence Lifetime Imaging – Applications and Instrumental Principles
  • High-Speed Localization Microscopy and Single-Particle Tracking
  • Intravital Microscopy in Mammalian Organisms: From Tissue Physiology to Cell Biology
  • Optogenetics
  • ORGANELLES
  • STRUCTURE AND FUNCTION
  • The Endoplasmic Reticulum
  • Intermediate Compartment: A Sorting Station between the Endoplasmic Reticulum and the Golgi Apparatus
  • Golgi and TGN
  • Early Endosomal Compartments
  • The Late Endosome
  • Signaling from Endosomes
  • Conventional and Secretory Lysosomes
  • Lysosome-Related Organelles
  • At the Center of Autophagy: Autophagosomes
  • Peroxisomes
  • Lipid Droplets
  • Mechanisms and Functions of Mitochondrial Dynamics
  • Synaptosomes and Synaptic Vesicles
  • Extracellular Vesicles
  • Nuclear Organization (Nuclear Structure and Dynamics)
  • Nuclear Pores
  • Plastids: The Anabolic Factories of Plant Cells
  • INTERORGANELLAR COMMUNICATION
  • INTERPLAY AND PROCESSES
  • ER–Golgi Transport
  • N-Linked Glycans (N-Glycans)
  • Extracellular O-Glycans
  • Intra-Golgi Transport
  • Post-Golgi Transport – Cargo, Carriers, and Pathways
  • Regulation of the Secretory Pathway
  • Regulated versus Constitutive Secretion – A Major Form of Intercellular Communication
  • Clathrin and Clathrin-Dependent Endocytosis
  • Clathrin Independent Endocytosis
  • Rabs of the Endosomal Recycling Pathway
  • Endosome to Lysosome Transport
  • Endocytosis of Cargo Proteins: LDL
  • Retrograde Transport
  • Rabs and Other G Proteins
  • COMPONENTS
  • Adaptor Proteins: Inter-Organelle Traffic Controllers
  • SNAREs: Membrane Fusion and Beyond
  • ESCRTing around the Cell
  • The Retromer Complex
  • Vesicle Tethers
  • BAR Domains and BAR Domain Superfamily Proteins
  • INTERPLAY AND PROCESSES
  • Role of Phosphoinositides in Membrane Traffic
  • Unconventional Protein Secretion: Fibroblast Growth Factor 2 and Interleukin-1β as Examples
  • Endoplasmic Reticulum Stress in Disease
  • CYTOSKELETON AND MOTORS
  • CYTOSKELETAL COMPONENTS
  • Microtubules and Microtubule-Associated Proteins (MAPs)
  • Actin Assembly Dynamics and Its Regulation in Motile and Morphogenetic Processes
  • Intermediate Filaments
  • Septins: Cytoskeletal Filaments with Structural and Regulatory Functions
  • Bacterial and Archaeal Cytoskeletons
  • Myosins
  • Kinesin Superfamily Proteins (KIFs) as a Fundamental Component of Life: Intracellular Transport and Beyond
  • Dyneins
  • COMPLEX CYTOSKELETAL STRUCTURES
  • The Mitotic Spindle
  • Centrioles and the Centrosome
  • Cilia and Flagella
  • Skeletal Muscle
  • Filopodia and Lamellipodia
  • The Extracellular Matrix
  • Cell–Cell Adhesion and the Cytoskeleton
  • Cell Adhesion to the Extracellular Matrix
  • Cell Migration
  • Rho GTPases
  • Cell Polarity
  • INTRACELLULAR INFECTIOLOGY
  • CELL PROCESSES
  • Phagocytosis
  • Macropinocytosis
  • Microbicidal Mechanisms
  • Bacterial Subversion of Phagocytic Killing
  • Cellular Invasion by Bacterial Pathogens
  • INFECTIOUS AGENTS
  • Bacterial Protein Toxins as Tools in Cell Biology and Physiology
  • The Gut Microbiome
  • Cell Biology of Virus Infection
  • Virus Factories and Mini-Organelles Generated for Virus Replication
  • HIV – The Cell Biology of Virus Infection and Replication
  • Prions
  • CELL PROCESSES
  • Cellular Responses to Infections in Caenorhabditis elegans
  • Volume 3: Functional Cell Biology
  • Functional Cell Biology: An Overview
  • CELL COMMUNICATION
  • GROWTH FACTOR MEDIATED CELL SIGNALING
  • Receptor Tyrosine Kinases and Their Ligands
  • Cytokine Receptors and Their Ligands
  • TGF-β Superfamily Signaling
  • G Protein-Coupled Receptors
  • Guanylyl Cyclase Receptors
  • Tumor Necrosis Factor Receptors: A Brief Digestion
  • Signaling and Function of Death Receptors of the Tumor Necrosis Factor Receptor Superfamily
  • Hedgehog Signaling in Development and Disease
  • The Wnt/β-Catenin Pathway
  • The Hippo Pathway
  • The Notch Pathway
  • INTRACELLULAR PATHWAYS
  • SH3 and SH2: Prototypic Domains to Mediate Regulatory Mechanisms in the Cell
  • The MAPK Signaling Cascades
  • The PI3K/Akt/mTOR Pathway
  • The JAK–STAT–SOCS Signaling Cascade
  • The PLC Pathway
  • Calcium and Calmodulin Signaling
  • CELLULAR MACHINERIES
  • Macromolecular Communication between Nucleus and Cytoplasm
  • The Molecular Architecture of Cell–Cell Adhesions
  • Extracellular Regulation of Cell-to-Matrix Adhesion
  • CELLULAR OUTCOMES
  • Regulation of Cell Polarity
  • Regulation of Cell Migration
  • PROTOTYPIC INTEGRATIVE PROCESSES
  • Wound Healing: An Orchestrated Process of Cell Cycle, Adhesion, and Signaling
  • Cancer Cell Invasion through Tissue Barriers
  • Neuronal Transport and Spatial Signaling Mechanisms in Neural Repair
  • CELL DIVISION/DEATH
  • REGULATION OF CELL GROWTH
  • mTORC1: Upstream and Downstream
  • The Nucleolus
  • Ribosomes and Stress – Linked from Birth to Death
  • Extra-Ribosome Functions of Ribosomal Proteins
  • Ribosomal RNA Processing
  • Eukaryotic Ribosome Assembly and Export
  • Internal Ribosome Entry Site-Mediated Translation
  • Targeted mRNA Degradation
  • APOPTOSIS
  • Apoptosis
  • Anoikis
  • Mitochondria in Cell Death Regulation
  • Tumor Necrosis Factor Signaling Pathways
  • Caspases
  • Efferocytosis in the Tumor Microenvironment
  • The Bcl-2 Family Proteins: Insights into Their Mechanism of Action and Therapeutic Potential
  • Inhibitor of Apoptosis Proteins, the Sentinels of Cell Death and Signaling
  • Mitotic Catastrophe
  • Autophagy
  • CELL CYCLE
  • Interplay between Oncogenes and Tumor Suppressor Genes in Human Disease
  • Cyclins and Cyclin-Dependent Kinases
  • The Restriction Point
  • CDK Inhibitors in Normal and Malignant Cells
  • The INK4a/ARF Locus
  • S Phase
  • Traveling through Mitosis with the Chromosomal Passenger Complex
  • Mitosis in Animal Cells
  • Regulating Cytokinesis
  • Regulation of the p53 Pathway
  • Cellular Senescence
  • CELLULAR IMMUNOLOGY
  • OVERVIEW
  • Introduction to Functional Cell Biology of Immunity
  • TRANSCRIPTIONAL BASIS OF B AND T CELL LINEAGES AND MEMORY CELLS
  • The T-Cell Receptor Signalosome
  • T Follicular Helper Cells
  • V(D)J Recombination: Orchestrating Diversity without Damage
  • T Cell Memory to Viral Infections
  • Nuclear Factor of Activated T Cells and Tolerance
  • NF-kappaB and the Immune System
  • CELL–CELL INTERACTIONS AND THE IMMUNE SYSTEM
  • Functional Specialization of Dendritic Cell Subsets
  • CD28 Costimulation and Regulatory T Cells
  • Roles of Stromal Cells in the Immune System
  • CXCL12/SDF-1 and Hematopoiesis
  • Lymphocyte–Endothelial Interactions
  • T Cell Receptor Triggering
  • Single Molecule Methods to Measure Receptor–Ligand Interaction in Immunological Synapses
  • Single-Cell Interrogation of the Immune System Using Microtools
  • Cellular Structures Controlling T Cell Signaling in Time and Space
  • INNATE IMMUNITY
  • Function of Epithelial Barriers
  • Phagocytic Synapses
  • The Phagocyte NADPH Oxidase: Structure and Assembly of the Key Multicomponent Enzyme of Innate Immunity
  • Cytoplasmic Sensing in Innate Immunity
  • Scavenger Receptors
  • Dendritic Cells
  • Neutrophil Biology
  • Specialized Subsets of Tissue-Resident Macrophages in Secondary Lymphoid Organs
  • CD4 T Cell Memory and Role of TNF Receptor Family
  • STEM CELL BIOLOGY
  • STRUCTURE AND FUNCTION
  • Stem Cells and Aging
  • Epigenetic Regulation of Stem Cells
  • The Adult Stem Cell Niche: Multiple Cellular Players in Tissue Homeostasis and Regeneration
  • Cancer Stem Cells
  • Metabolic and Energetic Regulation of Stem Cells
  • Pluripotent Cells: New Tools for Disease Research and Therapies
  • Volume 4: Systems Cell Biology
  • Systems Cell Biology: An Overview
  • DYNAMIC INTEGRATION
  • DYNAMICS
  • Dynamics of Gradient Sensing and Chemotaxis
  • Modeling Actin Dynamics
  • Metabolism
  • Dynamics of Microtubule Self-Assembly
  • Dynamics of Protein Kinase Cascades
  • Cdc42 and the Mechanisms of Yeast Cell Polarization – A Paradigm for Mesoscale Systems Biology
  • Theory of Cargo and Membrane Trafficking
  • Transcription Factor Networks
  • VERTICAL INTEGRATION
  • MODELING
  • Vertical Integration
  • Computational Approaches for Multiscale Modeling
  • Cardiac Modeling
  • APPLICATIONS
  • Mathematical Approaches to Studying Inflammation
  • Angiogenesis
  • A Review on Various Mathematical Modeling Approaches for Wound Healing
  • Multiscale Analysis of Morphogenesis
  • Neurogenesis in the Adult Brain
  • HORIZONTAL INTEGRATION
  • NETWORKS
  • Understanding of ‘Networks’ In Vitro and/or In Vivo
  • OMICS
  • Connecting Evolutionary Genomics to Cell Biology
  • Transcriptomics
  • The Advent of Mass Spectrometry-Based Proteomics in Systems Biology Research
  • Phosphoproteomics: Approaches, Developments, and Challenges
  • Interactomes – Scaffolds of Cellular Systems
  • Metabolomics in Cell Biology
  • ANALYSES AND TOOLS
  • Network Modeling of Heterogeneous Datasets
  • Stochastic Analysis of Nongenetic Cell-to-Cell Heterogeneity
  • Systematic Methods to Interrogate Genetic Perturbations and Map Phosphorylation-Dependent Signaling
  • High-Content Screening in Cell Biology
  • Integrative Systems Biology
  • DISEASE
  • Computational and Systems Cancer Biology
  • Drug Targeting