Encyclopedia of Cell Biology
Encyclopedia of Cell Biology
Editors: Bradshaw, Ralph A. and Stahl, Philip D.
Publication Year: 2015
Publisher: Elsevier Science & Technology
Single-User Purchase Price:
$2520.00

Unlimited-User Purchase Price:
$3780.00
ISBN: 978-0-12-394447-4
Category: Science - Biology
Image Count:
1816
Video Count:
27
Book Status: Available
Table of Contents
The Encyclopedia of Cell Biology offers a broad overview of cell biology, offering reputable, foundational content for researchers and students across the biological and medical sciences.
Table of Contents
- Dedication
- Editors-in-Chief
- Volume Editors
- Section Editors
- Preface
- Cell Biology: An Overview
- Permission Acknowledgments
- Volume 1: Molecular Cell Biology
- Molecular Cell Biology: An Overview
- MOLECULAR PRINCIPLES, COMPONENTS, TECHNOLOGY, AND CONCEPTS
- BASIC PRINCIPLES
- Chemical and Physical Principles
- Biocatalysis
- NUCLEIC ACIDS
- DNA, RNA Chemical Properties (Including Sequencing and Next-Generation Sequencing)
- The Chemical Synthesis of DNA and RNA Oligonucleotides for Drug Development and Synthetic Biology Applications
- PROTEINS
- Expression Systems
- Isolation/Purification of Proteins
- Protein Sequence Determination: Methodology and Evolutionary Implications
- Posttranslational Modifications: Key Players in Health and Disease
- Protein Domains: Structure, Function, and Methods
- NMR in Structural and Cell Biology
- Proteins: Folding, Misfolding, Disordered Proteins, and Related Diseases
- Diseases of Protein Folding: Huntington’s Disease and Amyotrophic Lateral Sclerosis
- Site-Directed Mutagenesis
- Chemical Biology
- Drug Design
- Antibodies and Improved Engineered Formats (as Reagents)
- LIPIDS
- Lipidomics
- Synthesis and Structure of Glycerolipids
- Cholesterol and Other Steroids
- Glycolipids
- Lipid Signaling
- MEMBRANES
- Composition, Physical Properties, and Curvature
- Lipid Rafts/Membrane Rafts
- Membrane Potential: Concepts
- The Outer Mitochondrial Membrane, a Smooth ‘Coat’ with Many Holes and Many Roles: Preparation, Protein Components, Interactions with Other Membranes, Involvement in Health, Disease, and as a Drug Target
- Neuronal Action Potentials and Ion Channel Allostery
- Cystic Fibrosis
- CARBOHYDRATES
- Glycogen and Starch
- Proteoglycans
- Hyaluronan
- METABOLISM
- Metabolic Regulation
- A Structure Perspective on Organelle Bioenergetics
- NUCLEIC ACID SYNTHESIS/BREAKDOWN
- RNA SYNTHESIS/FUNCTION
- Transfer RNA
- Messenger RNA (mRNA): The Link between DNA and Protein
- The Interplay between Eukaryotic mRNA Degradation and Translation
- miRNAs/Small Noncoding RNAs
- Small RNAs/Cancer
- Riboswitches and Ribozymes
- Ribosomal RNAs and Protein Synthesis
- Comparison of Bacterial and Eukaryotic Replisome Components
- DNA SYNTHESIS/REPAIR
- Telomeres and Telomerase
- Telomere Biology
- Eukaryotic Nucleotide Excision Repair
- The Base Excision Repair Pathway
- Nonhomologous DNA End Joining
- DNA Repair by Homologous Recombination
- TRANSCRIPTION
- Prokaryotic Transcription
- Eukaryotic Transcriptional Regulation
- Distant Activation of Transcription by Enhancers
- The Spliceosome and Pre-mRNA Splicing
- Pre-mRNA Splicing: Function and Dysfunction
- NUCLEIC ACID TECHNOLOGY
- Transgenesis and Gene Replacement
- Viral Nucleic Acids
- PROTEIN SYNTHESIS/DEGRADATION
- TRANSLATION
- Components, Initiation, Elongation, Termination, and Regulation
- Biogenesis of Secretory Proteins
- The Protein Biosynthetic Machinery of Mitochondria
- Regulated Proteolysis of Signaling Molecules: The Proprotein Convertases
- PROTEIN DEGRADATION – GENERAL
- Mass Spectrometry-based Methodologies for Studying Proteolytic Networks and the Degradome
- PROTEIN DEGRADATION – INTRACELLULAR
- Ubiquitin, Ubiquitin-Like Proteins, and Proteasome-Mediated Degradation
- Endoplasmic Reticulum-Associated Degradation and Protein Quality Control
- Role of Lysosomes in Intracellular Degradation
- PROTEIN DEGRADATION – PROTEASE CLASSES
- Matrix Metalloproteinases
- ADAMTS Proteases: Mediators of Physiological and Pathogenic Extracellular Proteolysis
- ADAMs Regulate Cell–Cell Interactions by Controlling the Function of the EGF-Receptor, TNFα and Notch
- Extracellular: Plasma Membrane Proteases – Serine Proteases
- Aspartic Proteases of Alzheimer’s Disease: β- and γ-Secretases
- The Calpain Proteolytic System
- Cathepsin E: An Aspartic Protease with Diverse Functions and Biomedical Implications
- Metalloproteases Meprin α and Meprin β in Health and Disease
- Kallikrein
- Naturally-Occurring Polypeptide Inhibitors: Cystatins/Stefins, Inhibitors of Apoptosis (IAPs), Serpins, and Tissue Inhibitors of Metalloproteinases (TIMPs)
- PROTEOLYTIC PATHWAYS
- Overview of Blood Coagulation and the Pathophysiology of Blood Coagulation Disorders
- Molecular Mechanisms Underlying the Actions of the Complement System
- Digestive Proteases: Roles in the Human Alimentary Tract
- PROTEIN DEGRADATION – PATHOLOGICAL ASPECTS
- Inhibitors of HIV Protease
- Blood Pressure, Proteases and Inhibitors
- Cancer – Proteases in the Progression and Metastasis
- Lysosomal Diseases
- Alpha-1-Antitrypsin Deficiency: A Misfolded Secretory Glycoprotein Damages the Liver by Proteotoxicity and Its Reduced Secretion Predisposes to Emphysematous Lung Disease Because of Protease-Inhibitor Imbalance
- Volume 2: Organizational Cell Biology
- Organizational Cell Biology: An Overview
- IMAGING THE CELL
- ELECTRON MICROSCOPY
- Single-Particle CryoEM of Macromolecular Complexes
- Scanning Electron Microscopy in Cell Biology
- Electron Tomography
- Immunoelectron Microscopy: High-Resolution Immunocytochemistry
- Imaging Cellular Architecture with 3D SEM
- LIGHT MICROSCOPY
- Genetically Encoded Fluorescent Probes and Live Cell Imaging
- Total Internal Reflection Fluorescence Microscopy
- Super Resolution Fluorescence Localization Microscopy
- Super-Resolution Light Microscopy: Stimulated Emission Depletion and Ground-State Depletion
- Structured Illumination Microscopy
- Fluorescence Correlation Spectroscopy: A Tool for Measuring Dynamic and Equilibrium Properties of Molecules in Cells
- Fluorescence Lifetime Imaging – Applications and Instrumental Principles
- High-Speed Localization Microscopy and Single-Particle Tracking
- Intravital Microscopy in Mammalian Organisms: From Tissue Physiology to Cell Biology
- Optogenetics
- ORGANELLES
- STRUCTURE AND FUNCTION
- The Endoplasmic Reticulum
- Intermediate Compartment: A Sorting Station between the Endoplasmic Reticulum and the Golgi Apparatus
- Golgi and TGN
- Early Endosomal Compartments
- The Late Endosome
- Signaling from Endosomes
- Conventional and Secretory Lysosomes
- Lysosome-Related Organelles
- At the Center of Autophagy: Autophagosomes
- Peroxisomes
- Lipid Droplets
- Mechanisms and Functions of Mitochondrial Dynamics
- Synaptosomes and Synaptic Vesicles
- Extracellular Vesicles
- Nuclear Organization (Nuclear Structure and Dynamics)
- Nuclear Pores
- Plastids: The Anabolic Factories of Plant Cells
- INTERORGANELLAR COMMUNICATION
- INTERPLAY AND PROCESSES
- ER–Golgi Transport
- N-Linked Glycans (N-Glycans)
- Extracellular O-Glycans
- Intra-Golgi Transport
- Post-Golgi Transport – Cargo, Carriers, and Pathways
- Regulation of the Secretory Pathway
- Regulated versus Constitutive Secretion – A Major Form of Intercellular Communication
- Clathrin and Clathrin-Dependent Endocytosis
- Clathrin Independent Endocytosis
- Rabs of the Endosomal Recycling Pathway
- Endosome to Lysosome Transport
- Endocytosis of Cargo Proteins: LDL
- Retrograde Transport
- Rabs and Other G Proteins
- COMPONENTS
- Adaptor Proteins: Inter-Organelle Traffic Controllers
- SNAREs: Membrane Fusion and Beyond
- ESCRTing around the Cell
- The Retromer Complex
- Vesicle Tethers
- BAR Domains and BAR Domain Superfamily Proteins
- INTERPLAY AND PROCESSES
- Role of Phosphoinositides in Membrane Traffic
- Unconventional Protein Secretion: Fibroblast Growth Factor 2 and Interleukin-1β as Examples
- Endoplasmic Reticulum Stress in Disease
- CYTOSKELETON AND MOTORS
- CYTOSKELETAL COMPONENTS
- Microtubules and Microtubule-Associated Proteins (MAPs)
- Actin Assembly Dynamics and Its Regulation in Motile and Morphogenetic Processes
- Intermediate Filaments
- Septins: Cytoskeletal Filaments with Structural and Regulatory Functions
- Bacterial and Archaeal Cytoskeletons
- Myosins
- Kinesin Superfamily Proteins (KIFs) as a Fundamental Component of Life: Intracellular Transport and Beyond
- Dyneins
- COMPLEX CYTOSKELETAL STRUCTURES
- The Mitotic Spindle
- Centrioles and the Centrosome
- Cilia and Flagella
- Skeletal Muscle
- Filopodia and Lamellipodia
- The Extracellular Matrix
- Cell–Cell Adhesion and the Cytoskeleton
- Cell Adhesion to the Extracellular Matrix
- Cell Migration
- Rho GTPases
- Cell Polarity
- INTRACELLULAR INFECTIOLOGY
- CELL PROCESSES
- Phagocytosis
- Macropinocytosis
- Microbicidal Mechanisms
- Bacterial Subversion of Phagocytic Killing
- Cellular Invasion by Bacterial Pathogens
- INFECTIOUS AGENTS
- Bacterial Protein Toxins as Tools in Cell Biology and Physiology
- The Gut Microbiome
- Cell Biology of Virus Infection
- Virus Factories and Mini-Organelles Generated for Virus Replication
- HIV – The Cell Biology of Virus Infection and Replication
- Prions
- CELL PROCESSES
- Cellular Responses to Infections in Caenorhabditis elegans
- Volume 3: Functional Cell Biology
- Functional Cell Biology: An Overview
- CELL COMMUNICATION
- GROWTH FACTOR MEDIATED CELL SIGNALING
- Receptor Tyrosine Kinases and Their Ligands
- Cytokine Receptors and Their Ligands
- TGF-β Superfamily Signaling
- G Protein-Coupled Receptors
- Guanylyl Cyclase Receptors
- Tumor Necrosis Factor Receptors: A Brief Digestion
- Signaling and Function of Death Receptors of the Tumor Necrosis Factor Receptor Superfamily
- Hedgehog Signaling in Development and Disease
- The Wnt/β-Catenin Pathway
- The Hippo Pathway
- The Notch Pathway
- INTRACELLULAR PATHWAYS
- SH3 and SH2: Prototypic Domains to Mediate Regulatory Mechanisms in the Cell
- The MAPK Signaling Cascades
- The PI3K/Akt/mTOR Pathway
- The JAK–STAT–SOCS Signaling Cascade
- The PLC Pathway
- Calcium and Calmodulin Signaling
- CELLULAR MACHINERIES
- Macromolecular Communication between Nucleus and Cytoplasm
- The Molecular Architecture of Cell–Cell Adhesions
- Extracellular Regulation of Cell-to-Matrix Adhesion
- CELLULAR OUTCOMES
- Regulation of Cell Polarity
- Regulation of Cell Migration
- PROTOTYPIC INTEGRATIVE PROCESSES
- Wound Healing: An Orchestrated Process of Cell Cycle, Adhesion, and Signaling
- Cancer Cell Invasion through Tissue Barriers
- Neuronal Transport and Spatial Signaling Mechanisms in Neural Repair
- CELL DIVISION/DEATH
- REGULATION OF CELL GROWTH
- mTORC1: Upstream and Downstream
- The Nucleolus
- Ribosomes and Stress – Linked from Birth to Death
- Extra-Ribosome Functions of Ribosomal Proteins
- Ribosomal RNA Processing
- Eukaryotic Ribosome Assembly and Export
- Internal Ribosome Entry Site-Mediated Translation
- Targeted mRNA Degradation
- APOPTOSIS
- Apoptosis
- Anoikis
- Mitochondria in Cell Death Regulation
- Tumor Necrosis Factor Signaling Pathways
- Caspases
- Efferocytosis in the Tumor Microenvironment
- The Bcl-2 Family Proteins: Insights into Their Mechanism of Action and Therapeutic Potential
- Inhibitor of Apoptosis Proteins, the Sentinels of Cell Death and Signaling
- Mitotic Catastrophe
- Autophagy
- CELL CYCLE
- Interplay between Oncogenes and Tumor Suppressor Genes in Human Disease
- Cyclins and Cyclin-Dependent Kinases
- The Restriction Point
- CDK Inhibitors in Normal and Malignant Cells
- The INK4a/ARF Locus
- S Phase
- Traveling through Mitosis with the Chromosomal Passenger Complex
- Mitosis in Animal Cells
- Regulating Cytokinesis
- Regulation of the p53 Pathway
- Cellular Senescence
- CELLULAR IMMUNOLOGY
- OVERVIEW
- Introduction to Functional Cell Biology of Immunity
- TRANSCRIPTIONAL BASIS OF B AND T CELL LINEAGES AND MEMORY CELLS
- The T-Cell Receptor Signalosome
- T Follicular Helper Cells
- V(D)J Recombination: Orchestrating Diversity without Damage
- T Cell Memory to Viral Infections
- Nuclear Factor of Activated T Cells and Tolerance
- NF-kappaB and the Immune System
- CELL–CELL INTERACTIONS AND THE IMMUNE SYSTEM
- Functional Specialization of Dendritic Cell Subsets
- CD28 Costimulation and Regulatory T Cells
- Roles of Stromal Cells in the Immune System
- CXCL12/SDF-1 and Hematopoiesis
- Lymphocyte–Endothelial Interactions
- T Cell Receptor Triggering
- Single Molecule Methods to Measure Receptor–Ligand Interaction in Immunological Synapses
- Single-Cell Interrogation of the Immune System Using Microtools
- Cellular Structures Controlling T Cell Signaling in Time and Space
- INNATE IMMUNITY
- Function of Epithelial Barriers
- Phagocytic Synapses
- The Phagocyte NADPH Oxidase: Structure and Assembly of the Key Multicomponent Enzyme of Innate Immunity
- Cytoplasmic Sensing in Innate Immunity
- Scavenger Receptors
- Dendritic Cells
- Neutrophil Biology
- Specialized Subsets of Tissue-Resident Macrophages in Secondary Lymphoid Organs
- CD4 T Cell Memory and Role of TNF Receptor Family
- STEM CELL BIOLOGY
- STRUCTURE AND FUNCTION
- Stem Cells and Aging
- Epigenetic Regulation of Stem Cells
- The Adult Stem Cell Niche: Multiple Cellular Players in Tissue Homeostasis and Regeneration
- Cancer Stem Cells
- Metabolic and Energetic Regulation of Stem Cells
- Pluripotent Cells: New Tools for Disease Research and Therapies
- Volume 4: Systems Cell Biology
- Systems Cell Biology: An Overview
- DYNAMIC INTEGRATION
- DYNAMICS
- Dynamics of Gradient Sensing and Chemotaxis
- Modeling Actin Dynamics
- Metabolism
- Dynamics of Microtubule Self-Assembly
- Dynamics of Protein Kinase Cascades
- Cdc42 and the Mechanisms of Yeast Cell Polarization – A Paradigm for Mesoscale Systems Biology
- Theory of Cargo and Membrane Trafficking
- Transcription Factor Networks
- VERTICAL INTEGRATION
- MODELING
- Vertical Integration
- Computational Approaches for Multiscale Modeling
- Cardiac Modeling
- APPLICATIONS
- Mathematical Approaches to Studying Inflammation
- Angiogenesis
- A Review on Various Mathematical Modeling Approaches for Wound Healing
- Multiscale Analysis of Morphogenesis
- Neurogenesis in the Adult Brain
- HORIZONTAL INTEGRATION
- NETWORKS
- Understanding of ‘Networks’ In Vitro and/or In Vivo
- OMICS
- Connecting Evolutionary Genomics to Cell Biology
- Transcriptomics
- The Advent of Mass Spectrometry-Based Proteomics in Systems Biology Research
- Phosphoproteomics: Approaches, Developments, and Challenges
- Interactomes – Scaffolds of Cellular Systems
- Metabolomics in Cell Biology
- ANALYSES AND TOOLS
- Network Modeling of Heterogeneous Datasets
- Stochastic Analysis of Nongenetic Cell-to-Cell Heterogeneity
- Systematic Methods to Interrogate Genetic Perturbations and Map Phosphorylation-Dependent Signaling
- High-Content Screening in Cell Biology
- Integrative Systems Biology
- DISEASE
- Computational and Systems Cancer Biology
- Drug Targeting