Encyclopedia of Immunobiology

Editor: Ratcliffe, Michael
Publication Year: 2016
Publisher: Elsevier Science & Technology

Single-User Purchase Price: $2352.00
Unlimited-User Purchase Price: $3528.00
ISBN: 978-0-12-374279-7
Category: Science - Biology
Image Count: 801
Book Status: Available
Table of Contents

As the largest integrated source of immunological knowledge currently available, Encyclopedia of Immunobiology is a go-to reference for students and professionals alike, providing relevant topics to those working on experimental and clinical immunology, microbiology, biochemistry, genetics, veterinary science, physiology, and hematology.

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Table of Contents

  • Editor in Chief
  • Volume Editors
  • Guide to Using the Encyclopedia
  • Preface
  • Permission Acknowledgments
  • Volume 1 Development and Phylogeny of the Immune System
  • Myeloid and B Cell Development
  • Ontogeny of the Hematopoietic System
  • Adult Hematopoiesis
  • Myelopoiesis
  • Molecular Mechanisms of Stable Lineage Identity in Early B-Lymphocyte Development
  • Fetal B Cell Development
  • B-1 B Cell Development
  • Pre-BCR
  • Regulation of Igh Recombination and Allelic Exclusion
  • Regulation of IgL Chain Recombination
  • Central B Cell Tolerance
  • Mechanisms of Peripheral B Cell Tolerance
  • BAFF and B Cell Development, Homeostasis, and Selection
  • Marginal Zone B Cell Development
  • Human B Cell Development and Tolerance
  • Human B Cell Subsets
  • B Cell Development in Birds
  • B Cell Development in Mucosa-Associated Lymphoid Tissues
  • Development of T Cells and Innate Lymphoid Cells
  • Development of Natural Killer Cells and ILC1
  • Development of Group 2 Innate Lymphoid Cells
  • Innate Lymphoid Cells Type 3
  • Development of Thymic Epithelial Cells
  • Notch Functions in T Cell Development
  • Orchestration of T Cell Development by Common γ Chain Cytokines
  • Transcriptional Regulation of T Cell Lineage Commitment
  • Transcriptional and Microenvironmental Regulation of γδ T Cell Development
  • Production of the Semi-Invariant TCR and PLZF Function in Innate Programming of iNKT Cells
  • CD4/CD8 Lineage Commitment
  • Control of Early T Cell Development by Notch and T Cell Receptor Signals
  • TCR Affinity and Signaling during Thymocyte Selection
  • Control of Migration during Intrathymic T Cell Development
  • Thymocyte–mTEC Cross Talk for Self-Tolerance in T Cells
  • Development of Regulatory T Cells in the Thymus
  • DN TCRαβ Intraepithelial T Cell Development in the Thymus
  • Cells of the Innate Immune System
  • Neutrophils – Role in Innate Immunity
  • Macrophage Activation and Polarization
  • Kupffer Cells in Immunity
  • Microglia – Role in Immunity
  • Mast Cells in Allergy, Host Defense, and Immune Regulation
  • Basophils – Role in Immunity
  • Eosinophils
  • Dendritic Cells and Dendritic Cell Subsets
  • Natural Killer Cells
  • The Role of Invariant NKT Cells in Immunity
  • Polymorphic KIR-HLA System Regulates Natural Killer Cell Response
  • ILC2 in Immunity
  • Phylogeny of the Immune System
  • Defense Mechanisms in Plants
  • Emergence of Immune System Components in Cnidarians
  • Molecular Evolution of Defense Pathways in Sponges: Self–Self-recognition and Fight against the Nonself
  • Immunity in Molluscs
  • The Immune System of Crustaceans
  • Immunity in Insects
  • The Immune System of Echinoderms
  • The Immune System of Agnathans (Jawless Vertebrates)
  • The Immune System and Immunity in Cartilaginous Fish
  • The Immune System of Bony Fish
  • The Immune System of Amphibians
  • The Immune System in Reptiles
  • The Avian Immune System
  • The Immune System of Monotremes and Marsupials
  • The Immune System of Lagomorphs
  • The Immune System of Sheep and Goats
  • The Immune System of Cattle
  • The Immune System of Swine
  • The Immune System of Horses and Other Equids
  • Volume 2 Molecular Immunology
  • Structure and Function of Diversifying Receptors
  • Structure, Function, and Production of Immunoglobulin M (IgM)
  • IgG Structure and Function
  • Structure and Function of IgA
  • Structure and Function of IgE
  • Structure, Function, and Spatial Organization of the B Cell Receptor
  • Genomic Organization of the Murine and Human IGH Locus
  • Genomic Organization of Murine and Human Immunoglobulin Light Chain Loci
  • Structure and Function of TCRαβ Receptors
  • Structure and Function of TCRγδ Receptors
  • Organization and Rearrangement of TCR Loci
  • The Role of RAG in V(D)J Recombination
  • NHEJ and Other Repair Factors in V(D)J Recombination
  • AID in Somatic Hypermutation and Class Switch Recombination
  • Error-Prone Mismatch and Base Excision DNA Repair in Somatic Hypermutation
  • DNA Repair during Class Switch Recombination
  • Immunoglobulin Diversification by Gene Conversion
  • Variable Lymphocyte Receptors: The Basis of Adaptive Immunity in Jawless Vertebrates
  • Structure and Function of Camelid VHH
  • Structure and Function of IgNARS in Sharks and Other Cartilaginous Fish
  • MHC Structure and Function
  • Genetics and Genomic Organization of the Major Histocompatibility Complex (MHC)
  • Structure of Classical Class I MHC Molecules
  • Structure of Nonclassical MHC I (HLA-E, HLA-F, HLA-G, and Orthologs)
  • Structure of Classical MHCII (HLA-DP, DQ, DR, and Orthologs)
  • Repertoire of Classical MHC Class I and Class II Molecules
  • The Peptide Ligands Presented by MHC Class II Molecules
  • Repertoire of Nonclassical MHC I (HLA-E, HLA-F, HLA-G, and Orthologues)
  • Immune Epitope Database and Analysis Resource
  • Origin and Processing of MHC-I Ligands
  • Ligand Selection and Trafficking for MHC I
  • Origin and Processing of MHC Class II Ligands
  • Ligand Selection and Trafficking for MHC II
  • Cluster of Differentiation 1 (CD1): A Family of Lipid Antigen-Presenting Molecules
  • MR1 (in Mouse and Man)
  • Structures and Functions of MHC-like Proteins
  • Molecular Immunoevasion Strategies Targeting Antigen Processing and Presentation
  • HLA and Autoimmunity
  • Genetic Associations of the Major Histocompatibility Complex (MHC) with Infectious Disease
  • HLA and Drug Hypersensitivity
  • Molecular Aspects of Innate Immunity
  • Classical Complement Pathway
  • Alternative Pathway of Complement
  • Inflammatory Products of the Complement Pathway
  • Proteolytic Cascades
  • The NOD-Like Receptors
  • Cytoplasmic Viral RNA Sensors: RIG-I-Like Receptors
  • Fc Receptors and Fc Receptor-Like Molecules within the Immunoreceptor Family
  • Scavenger Receptors
  • The Mucins
  • Peptidoglycan Recognition Proteins and Lysozyme
  • Regulation of Immune Cell Functions through Nectin and Nectin-Like Receptors
  • SLAM Family Receptors
  • Ectonucleotidases in Immunobiology
  • Neuroendocrine Peptides
  • Cytokines and their Receptors
  • The Interleukin-1 Family
  • Inflammasomes
  • Roles of TNF and Other Members of the TNF Family in the Regulation of Innate Immunity
  • Lymphotoxin
  • The Biology of Interleukin-6, a Major Target in Anti-Inflammatory Therapies
  • Interferon α/β
  • Interferon γ: An Overview of Its Functions in Health and Disease
  • New Interferons
  • γc Family Cytokines: Role in Immune Cell Development and Function
  • The Cellular and Molecular Network of IL-4 and IL-13
  • The IL-12/IL-23 Cytokine Family
  • Interleukin-17 Family
  • IL-10
  • The IL-20 Subfamily of Cytokines and Their Receptors
  • TGFβ
  • Function of Chemokines and Their Receptors in Immunity
  • Atypical Chemokine Receptors
  • Colony Stimulating Factors (CSFs)
  • Viral Anticytokine Strategies
  • Volume 3 Activation of the Immune System
  • Signal Transduction
  • TCR Signaling: Proximal Signaling
  • Adapter Molecules in Immune Receptor Signaling
  • Immunological Synapses
  • Kinase and Phosphatase Effector Pathways in T Cells
  • Cellular Metabolism Controls Lymphocyte Activation and Differentiation
  • Signal Transduction by the B Cell Antigen Receptor
  • Ubiquitin Signaling to NF-κB
  • Chemokine Receptor Signaling
  • Integrins: Regulation of Adhesion and Downstream Signaling
  • Signaling of Phagocytosis
  • Control of Cell Survival and Apoptosis
  • Signaling Pathways Downstream of TLRs and IL-1 Family Receptors
  • TNF Receptor Superfamily Signaling Pathways in Immune Cells
  • Structural Biology of JAK/STAT Cytokines and Their Receptors
  • Jak-STAT Signaling Pathways
  • Nuclear Receptors in Immune Function
  • B Cell Activation
  • Antigen Acquisition In Vivo and its Role in B Cell Activation
  • Regulation of B Cell Migration and Location in Response to Antigens
  • T Cell–Dependent B Cell Activation
  • Germinal Centers
  • Somatic Hypermutation and Class Switch Recombination
  • Memory B Cells
  • Long-Lived Plasma Cells
  • Extrafollicular Antibody Responses
  • Marginal Zone B Cell Responses to Antigens
  • The Humoral Immune Response to T Cell–Independent Antigens
  • Activation of B-1 Cells
  • Cytokine Regulation of B Cell Activation and Differentiation
  • B Cell–Associated Surface Molecules and B Cell Responses
  • TNF and TNFR Family Members and B Cell Activation
  • Cytokine-Producing Effector B Cells
  • Vaccines to Program Protective Humoral Immunity
  • B Cell Leukemia and Lymphoma
  • T Cell Activation
  • Th1 Cells
  • The Differentiation and Function of Th2 and Th9 Cells
  • Th17 and Th22 Cells
  • Treg Cells
  • γδ T Cell Functions and Biology
  • Modification of T Cell Functions at Sites of Infection and Inflammation
  • Recirculating and Resident Memory CD8+ T Cells
  • Transition of T Cells from Effector to Memory Phase
  • Cytotoxic Lymphocytes
  • Conventional Dendritic Cells: Identification, Subsets, Development, and Functions
  • Single T Cell Potential
  • Anatomy and Microanatomy of the Immune System
  • Thymic Microenvironments: Development, Organization, and Function
  • Structure and Function of the Bone Marrow Hematopoietic Niche
  • The Spleen
  • Lymph Node Structure
  • Anatomy and Microanatomy of Tonsils
  • Anatomy and Function of the Gut Immune System
  • Microanatomy and Immunity in the Liver
  • Skin Immune System: Microanatomy
  • Airway Immune System: Microanatomy
  • Central Nervous System: Microanatomy
  • Stromal Cells in Secondary Lymphoid Organs
  • Tertiary Lymphoid Tissues
  • Lymphocyte Recirculation
  • Effector T Lymphocyte Migration to and Within Non-Lymphoid Tissues
  • Leukocyte Adhesion Molecules
  • Blood Vascular Endothelial Adhesion Molecules
  • Endothelial Adhesion Molecules in the Lymphatic Vasculature
  • Roles of Chemokines in Immune Cell Trafficking to Lymphoid Tissues
  • S1P and LPA: Regulators of Immune Cell Egress and Ingress in Lymphoid Tissues
  • Volume 4 Immunity to Pathogens and Tumors
  • Immunity to Bacterial, Parasitic and Fungal Infections
  • Immunology of Bacterial and Parasitic Diseases: An Overview
  • Immunogenetics of Parasitic and Bacterial Disease
  • Immune-Driven Pathogen Evolution
  • Immunology of Tuberculosis
  • Systems Immunology: Approaches to Tuberculosis
  • Immunity to Enteropathogenic Escherichia coli
  • Immunity to Salmonella
  • Pneumococcal Biology, Diversity, Evolution and Host Responses to Infection
  • Immunology of Bacterial Biodefense Agents: Francisella tularensis, Burkholderia mallei, and Yersinia pestis
  • Immunology of Fungal Infections
  • Subverting Immunity from the Inside: Strategies of Intracellular Survival – Protozoans
  • Malaria, Immunity, and Immunopathology
  • Immunology of African Trypanosomiasis
  • Immunity to Trypanosoma cruzi
  • Immunology of Leishmaniasis
  • Toxoplasma gondii: Immune Protection and Evasion
  • Immunity to Intestinal Protozoa: Entamoeba, Cryptosporidium, and Giardia
  • Immunology of Lymphatic Filariasis
  • Immunology of Schistosomiasis
  • Immunology in Cestode Infections
  • The Hygiene Hypothesis and Immunity to Parasitic Helminths
  • Immunology of Central Nervous System Pathogens
  • Immunology of Prion Disease
  • Immunity to Viral Infections
  • Sensors of Viral Infection
  • Dendritic Cells in Viral Infection
  • Innate Cytokine Responses and Their Functions during Viral Infections
  • Intrinsic Cellular Defenses (TRIMS) in Modulating Viral Infection and Immunity
  • NK Cells in Antiviral Defense
  • NK Cells in T Cell Regulation
  • NK Cells in HIV-1 Infection
  • Chemokines and Viral Infections
  • Antibody Responses and Functions in Defense against Viral Infection
  • Activation of CD8 T Lymphocytes during Viral Infections
  • CD4 T Cell Immunity to Viral Infection
  • CD8 T Cell Memory to Pathogens
  • Protective and Pathogenic T Cell Responses to Virus Infections
  • T Cell Responses during Acute Respiratory Virus Infection
  • Immune Responses to Viruses in the CNS
  • Immunity to HIV
  • Ebola Virus
  • Immunity to Oncogenic Viruses
  • Human Genetic Defects Resulting in Increased Susceptibility to Viral Infections
  • Vaccination against Viruses
  • Tumor Immunology
  • Cancer Immunosurveillance: Immunoediting
  • Inflammation and Cancer
  • Tumor Antigens, Viral Origin
  • Stem Cell Antigens in Cancer
  • Personalized Immunotherapy Targeting the Cancer Mutanome
  • CD8 T Lymphocytes in Antitumor Immunity
  • CD4 T Cells in Antitumor Immunity
  • Regulatory T Cells in Tumor Immunity
  • NKT Cells in Tumor Immunity
  • B Cells and Regulatory B Cells in Cancer Escape
  • NK Cells in Antitumor Immunity
  • Tumor-Associated Macrophages
  • Dendritic Cells in the Tumor Microenvironment
  • Immune Suppressive Myeloid-Derived Suppressor Cells in Cancer
  • Soluble Mediators of Immune Suppression in the Tumor Microenvironment
  • Vaccines and Their Role in CD8 T Cell-Mediated Antitumor Immunity
  • Therapeutic and Prophylactic Cancer Vaccines
  • Antibody Therapy
  • From Adoptive Immunity to CAR Therapy: An Evolutionary Perspective
  • Combining Immunotherapies with Standard Therapies in the Treatment of Cancer
  • Volume 5 Physiology and Immune System Dysfunction
  • Physiology of the Immune System
  • The Intestinal Immune System
  • Immunology of the Liver
  • Immunology of the Eye
  • Immunology of the Skin
  • The Immunology of Adipose Tissue
  • Immunology of the Testis and Privileged Sites
  • Immunology of the Brain
  • Immunology of the Female Reproductive Mucosa
  • Immunity and the Endocrine System
  • Effect of Sex on Cellular Immunity
  • Effect of Sex on Humoral and Innate Immunity
  • Neonatal Immunity
  • Role of the Microbiota in Immune Development
  • Immunity and Nutrition: the Role of Vitamins
  • Immunity and Aging
  • Autoimmunity
  • Complex Genetic Control of Autoimmune Disease
  • Autoimmune Diseases Arising out of Single Gene Defects
  • Autoimmune Thyroid Disease
  • Type 1 Diabetes
  • Myasthenia Gravis
  • The Immunobiology of Multiple Sclerosis
  • Psoriasis, Cutaneous Lupus Erithematosus and Immunobiology of the Skin
  • Systemic Lupus Erythematosus
  • Rheumatoid Arthritis
  • The Immune Responses of Celiac Disease
  • Animal Models of Autoimmunity
  • Transplantation
  • Immune Tolerance in Hemopoietic Stem Cell Transplantation
  • Transplantation Immunology: Kidney and Liver
  • The Immunology of Pancreas Transplantation
  • Animal Models of Transplantation
  • Mesenchymal Stem Cells and Regenerative Medicine
  • Allergy
  • Allergens
  • Allergic Contact Dermatitis: Immune Reactions in the Skin
  • The Immunobiology of Asthma
  • Immunology of Nasal Polyposis and Allergic Rhinitis
  • Allergen Immunotherapy
  • Biologicals to Treat Allergy and Asthma
  • The Hygiene Hypothesis of Allergy and Asthma
  • Microbiome and Allergy
  • Immune Deficiency
  • Primary Immunodeficiencies: Clinical and Biological Guidelines
  • Thymus Abnormalities: DiGeorge Syndrome and Winged Helix Deficiency
  • Combined T Cell and B Cell Deficiency – SCID Forms: T−B+
  • Severe Combined Immune Deficiency with Absence of B and T Lymphocytes (T−B−NK+SCIDs): The Key Function of V(D)J Recombination for Lymphocyte Development
  • Major Histocompatibility Complex Class II Deficiency
  • Defects in T Cell Activation and Signaling
  • Familial Lymphohistiocytosis
  • Mendelian Susceptibility to Infections with Viruses, Mycobacteria, Bacteria, and Candida
  • Wiskott–Aldrich Syndrome, Leukocyte Adhesion Deficiency, and Other Migration Defects in Human Primary Immunodeficiency
  • Apoptosis-Related Autoimmune Lymphoproliferative Syndrome
  • Autoimmune Polyendocrinopathy–Candidiasis–Ectodermal Dystrophy (APECED)
  • Immunodysregulation, Polyendocrinopathy, and Enteropathy, X-Linked (IPEX) Syndrome
  • The Immunologic Complications and Genetic Origins of Telomere Disorders
  • Defects in B Cell Development
  • Defects in B Cell Survival and Activation
  • Immunoglobulin Class-Switch Recombination Defects
  • Chronic Granulomatous Disease
  • Monogenic Autoinflammatory Diseases
  • Clinical Significance of Complement Abnormalities
  • Principles of Treatment of Primary Immunodeficiencies
  • Author Index