Hoffbrand's Essential Haematology

Editor/Author Hoffbrand, Victor and Moss, Paul A. H.
Publication Year: 2016
Publisher: Wiley

Single-User Purchase Price: $73.99
Unlimited-User Purchase Price: $110.98
ISBN: 978-1-11-840867-4
Category: Health & Medicine - Medicine
Image Count: 338
Book Status: Available
Table of Contents

Hoffbrands Essential Haematology has built a reputation as the flagship haematology resource for students, providing an authoritative introduction to the subject. Now in its 7th edition, this classic text explores the remarkable advances in the understanding of the pathogenesis of diseases of the blood and lymphatic system and in the treatment of these diseases, and provides up-to-date knowledge of the pathogenesis, clinical and laboratory features, management and treatment of a wide range of blood and bone marrow disorders in a concise and user friendly style.

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Table of Contents

  • Preface to the Seventh Edition
  • Preface to the First Edition
  • 1 Haemopoiesis
  • Site of haemopoiesis
  • Haemopoietic stem and progenitor cells
  • Bone marrow stroma
  • The regulation of haemopoiesis
  • Haemopoietic growth factors
  • Growth factor receptors and signal transduction
  • Adhesion molecules
  • The cell cycle
  • Transcription factors
  • Epigenetics
  • Apoptosis
  • 2 Erythropoiesis and general aspects of anaemia
  • Blood cells
  • Erythropoietin
  • Haemoglobin
  • Red cell metabolism
  • Red cell membrane
  • Clinical features of anaemia
  • Classification and laboratory findings in anaemia
  • Assessment of erythropoiesis
  • 3 Hypochromic anaemias
  • Nutritional and metabolic aspects of iron
  • Iron absorption
  • Iron deficiency
  • Causes of iron deficiency
  • Laboratory findings
  • Treatment
  • Anaemia of chronic disorders
  • Sideroblastic anaemia
  • 4 Iron overload
  • Assessment of iron status and organ function
  • Hereditary (genetic, primary) haemochromatosis
  • Transfusional iron overload
  • Iron chelation therapy
  • 5 Megaloblastic anaemias and other macrocytic anaemias
  • Megaloblastic anaemias
  • Vitamin B12
  • Folate
  • Vitamin B12 deficiency
  • Folate deficiency
  • Clinical features of megaloblastic anaemia
  • Diagnosis of vitamin B12 or folate deficiency
  • Other megaloblastic anaemias
  • Other macrocytic anaemias
  • 6 Haemolytic anaemias
  • Normal red cell destruction
  • Introduction to haemolytic anaemias
  • Intravascular and extravascular haemolysis
  • Hereditary haemolytic anaemias
  • Acquired haemolytic anaemias
  • 7 Genetic disorders of haemoglobin
  • Haemoglobin synthesis
  • Haemoglobin abnormalities
  • Thalassaemias
  • α-Thalassaemias
  • β-Thalassaemias
  • Thalassaemia intermedia
  • Sickle cell anaemia
  • Prenatal diagnosis of genetic haemoglobin disorders
  • 8 The white cells 1: granulocytes, monocytes and their benign disorders
  • Granulocytes
  • Granulopoiesis
  • Clinical applications of myeloid growth factors
  • Monocytes
  • Disorders of neutrophil and monocyte function
  • Causes of leucocytosis and monocytosis
  • Neutropenia
  • Eosinophilia
  • Histiocytic disorders
  • Lysosomal storage diseases
  • 9 The white cells 2: lymphocytes and their benign disorders
  • Lymphocytes
  • Natural killer cells
  • Immunoglobulins
  • Antigen–receptor gene rearrangements
  • Complement
  • The immune response
  • Lymphocytosis
  • Immunodeficiency
  • Differential diagnosis of lymphadenopathy
  • 10 The spleen
  • The anatomy and circulation of the spleen
  • The functions of the spleen
  • Extramedullary haemopoiesis
  • Imaging the spleen
  • Splenomegaly
  • Hypersplenism
  • Hyposplenism
  • Splenectomy
  • Prevention of infection in hyposplenic patients
  • 11 The aetiology and genetics of haematological malignancies
  • The incidence of haematological neoplasms
  • The aetiology of haemopoietic malignancy
  • The genetics of haemopoietic malignancy
  • Chromosome nomenclature
  • Specific examples of genetic abnormalities in haematological malignancies
  • Diagnostic methods used to study malignant cells
  • Value of genetic markers in management of haematological malignancy
  • 12 Management of haematological malignancy
  • General support therapy
  • Insertion of a central venous catheter
  • Blood product support
  • Prophylaxis and treatment of infection
  • Specific therapies for haematological malignancy
  • Drugs used in the treatment of haemopoietic malignancies
  • 13 Acute myeloid leukaemia
  • Classification of leukaemia
  • Diagnosis of acute leukaemia
  • Acute myeloid leukaemia
  • Classification
  • Clinical features
  • Investigations
  • Treatment
  • Outcome
  • 14 Chronic myeloid leukaemia
  • Chronic myeloid leukaemia
  • Clinical features
  • Laboratory findings
  • Treatment
  • Accelerated phase disease and blastic transformation
  • Chronic neutrophilic leukaemia
  • Chronic eosinophilic leukaemia
  • 15 Myeloproliferative disease
  • Polycythaemia
  • Primary polycythaemia (erythrocytosis)
  • Polycythaemia vera
  • Secondary polycythaemia
  • Apparent polycythaemia
  • Differential diagnosis of polycythaemia
  • Essential thrombocythaemia
  • Primary myelofibrosis
  • Mastocytosis
  • 16 Myelodysplasia
  • Myelodysplasia (myelodysplastic syndromes)
  • Classification
  • Laboratory findings
  • Treatment
  • Myelodysplastic/myeloproliferative neoplasms
  • 17 Acute lymphoblastic leukaemia
  • Incidence and pathogenesis
  • Classification
  • Investigations
  • Treatment
  • Minimal residual disease
  • Specific therapy of ALL in adults
  • 18 The chronic lymphoid leukaemias
  • B-cell diseases
  • Chronic lymphocytic leukaemia
  • Pathogenesis
  • Clinical features
  • Laboratory findings
  • Treatment
  • Hairy cell leukaemia
  • T-cell diseases
  • 19 Hodgkin lymphoma
  • History and pathogenesis
  • Clinical features
  • Haematological and biochemical findings
  • Diagnosis and histological classification
  • Clinical staging
  • Treatment
  • Prognosis
  • The late effects of Hodgkin lymphoma and its treatment
  • 20 Non-Hodgkin lymphoma
  • Introduction to non-Hodgkin lymphoma
  • Clinical features of non-Hodgkin lymphoma
  • Laboratory investigation
  • Specific subtypes of non-Hodgkin lymphoma (NHL)
  • Lymphoplasmacytoid NHL
  • Marginal zone NHL
  • Follicular NHL
  • Mantle cell NHL
  • Diffuse large B-cell NHL
  • Burkitt lymphoma
  • T-cell lymphomas
  • 21 Multiple myeloma and related disorders
  • Paraproteinaemia
  • Multiple myeloma
  • Other plasma cell tumours
  • Monoclonal gammopathy of undetermined significance
  • Amyloidosis
  • Hyperviscosity syndrome
  • 22 Aplastic anaemia and bone marrow failure
  • Pancytopenia
  • Aplastic anaemia
  • Paroxysmal nocturnal haemoglobinuria
  • Red cell aplasia
  • Schwachman–Diamond syndrome
  • Congenital dyserythropoietic anaemia
  • Osteopetrosis
  • 23 Stem cell transplantation
  • Principles of stem cell transplantation
  • Peripheral blood stem cell collection
  • Bone marrow stem cell collection
  • Autologous stem cell transplantation
  • Allogeneic stem cell transplantation
  • Human leucocyte antigen (HLA) system
  • Complications
  • Graft-versus-leukaemia and donor leucocyte infusions
  • 24 Platelets, blood coagulation and haemostasis
  • Platelets
  • Blood coagulation
  • Endothelial cells
  • Haemostatic response
  • Fibrinolysis
  • Tests of haemostatic function
  • 25 Bleeding disorders caused by vascular and platelet abnormalities
  • Vascular bleeding disorders
  • Thrombocytopenia
  • Autoimmune (idiopathic) thrombocytopenic purpura
  • Thrombotic thrombocytopenic purpura
  • Disorders of platelet function
  • Diagnosis of platelet disorders
  • Platelet transfusions
  • 26 Coagulation disorders
  • Hereditary coagulation disorders
  • Haemophilia A
  • Factor IX deficiency
  • Von Willebrand disease
  • Hereditary deficiency of other coagulation factors
  • Acquired coagulation disorders
  • Disseminated intravascular coagulation
  • Massive transfusion
  • Thromboelastography: near-patient testing
  • 27 Thrombosis 1: pathogenesis and diagnosis
  • Arterial thrombosis
  • Venous thrombosis
  • Investigation of thrombophilia
  • Diagnosis of venous thrombosis
  • 28 Thombosis 2: treatment
  • Anticoagulant drugs
  • Heparin
  • Low molecular weight heparin
  • Direct-acting parenteral anticoagulants
  • Oral anticoagulants
  • Direct-acting oral anticoagulant drugs
  • Post-thrombotic syndrome
  • Mechanical methods of prophylaxis of venous thrombosis
  • Fibrinolytic agents
  • Antiplatelet drugs
  • 29 Haematological changes in systemic disease
  • Anaemia of chronic disorders
  • Haematological problems in the elderly
  • Malignant diseases
  • Rheumatoid arthritis
  • Renal failure
  • Congestive heart failure
  • Liver disease
  • Hypothyroidism
  • Infections
  • Non-specific monitoring of systemic disease
  • 30 Blood transfusion
  • Blood donor
  • Red cell antigens and blood group antibodies
  • Hazards of allogeneic blood transfusion
  • Techniques in blood group serology
  • Cross-matching and pre-transfusion tests
  • Complications of blood transfusion
  • Reduction of blood product use
  • Blood components
  • Preparations from human plasma
  • Acute blood loss
  • 31 Pregnancy and neonatal haematology
  • Haematology of pregnancy
  • Neonatal haematology
  • Haemolytic disease of the newborn
  • Appendix: World Health Organization classification of tumours of the haematopoietic and lymphoid tissues